TACE Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
TAPI-2 | 187034-31-7 | sc-205851 sc-205851A | 1 mg 5 mg | $286.00 $1019.00 | 15 | |
TAPI-2 is a potent TACE inhibitor that showcases remarkable specificity in its interactions with metalloproteinases. Its unique structure facilitates strong binding to the active site, effectively blocking substrate access. This compound exhibits distinct kinetic properties, allowing for a rapid onset of inhibition, which can modulate proteolytic activity. Additionally, TAPI-2's hydrophilic regions enhance solubility, promoting effective distribution in biological systems and influencing enzyme regulation. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Marimastat is a selective inhibitor of metalloproteinases, characterized by its ability to disrupt the catalytic activity of these enzymes through competitive binding. Its unique conformation allows for precise interactions with the active site, altering the enzyme's conformational dynamics. The compound exhibits a distinct kinetic profile, enabling a sustained inhibitory effect. Furthermore, Marimastat's structural features contribute to its stability in various environments, influencing its reactivity and interaction with biological substrates. | ||||||
TAPI-1 | 171235-71-5 | sc-222337 | 1 mg | $669.00 | 15 | |
TAPI-1 is a potent inhibitor of tumor necrosis factor-alpha converting enzyme (TACE), distinguished by its ability to selectively bind to the enzyme's active site. This binding alters the enzyme's structural dynamics, effectively hindering substrate access. TAPI-1 exhibits unique reaction kinetics, characterized by a rapid onset of inhibition followed by a prolonged effect. Its molecular design enhances solubility and stability, facilitating specific interactions that modulate TACE activity in diverse biochemical contexts. | ||||||
TAPI-0 | 143457-40-3 | sc-203410 sc-203410A | 1 mg 5 mg | $269.00 $1248.00 | 15 | |
TAPI-0 functions as a selective inhibitor of TACE, showcasing unique molecular interactions that disrupt the enzyme's catalytic mechanism. Its structure promotes strong non-covalent interactions with key residues, leading to a conformational shift that impedes substrate binding. The compound exhibits distinct reaction kinetics, with a gradual onset of inhibition that allows for sustained modulation of TACE activity. Additionally, TAPI-0's enhanced solubility contributes to its effective engagement in various biochemical environments. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
MMP inhibitor with TACE inhibition. Interferes with cell surface protein shedding and inflammatory processes. | ||||||
Prinomastat | 192329-42-3 | sc-507449 | 5 mg | $190.00 | ||
Hydroxamate-based MMP inhibitor, including TACE inhibition. Chelates TACE's active site zinc ion, blocking activity. | ||||||
RO-4929097 | 847925-91-1 | sc-364602 sc-364602A | 10 mg 50 mg | $439.00 $1417.00 | 1 | |
γ-secretase inhibitor with indirect TACE inhibition. Blocks proteolytic processing of substrates, including TNF-α. | ||||||
GW 280264X | 866924-39-2 | sc-507540 | 5 mg | $720.00 | ||
Inhibitor of TACE and related metalloproteinases. Modulates TACE activity, reducing shedding of cell surface proteins. | ||||||