MYBPC3 Antibody (F-1): sc-137181
- MYBPC3 Antibody (F-1) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 1-120 mapping at the N-terminus of MYBPC3 of human origin
- Anti-MYBPC3 Antibody (F-1) is recommended for detection of MYBPC3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MYBPC3 Antibody (F-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MYBPC3 Antibody (F-1) for WB applications. These reagents are now offered in bundles with MYBPC3 Antibody (F-1) (see ordering information below).
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MYBPC3 Antibody (F-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects MYBPC3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MYBPC3 (F-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MYBPC3, or myosin-binding protein C, cardiac, plays a crucial role in cardiac muscle function by regulating the interaction between myosin and actin filaments, which is essential for muscle contraction. MYBPC3 is predominantly located in the crossbridge-bearing zone of the A bands in vertebrate striated muscle, where MYBPC3 contributes to the structural integrity and functional regulation of the sarcomere. Proper localization of MYBPC3 is vital for maintaining the contractile properties of cardiac muscle, and any disruption in MYBPC3 function can lead to severe cardiac conditions. Notably, mutations in the MYBPC3 gene are associated with familial hypertrophic cardiomyopathy type 4 (CMH4), a genetic heart disorder characterized by ventricular hypertrophy, often affecting the interventricular septum asymmetrically. The MYBPC3 gene is located on chromosome 11p11.2, highlighting MYBPC3′s significance in cardiac health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MYBPC3 Antibody (F-1) References:
- Evidence from human myectomy samples that MYBPC3 mutations cause hypertrophic cardiomyopathy through haploinsufficiency. | Marston, S., et al. 2009. Circ Res. 105: 219-22. PMID: 19574547
- MYBPC3 in hypertrophic cardiomyopathy: from mutation identification to RNA-based correction. | Behrens-Gawlik, V., et al. 2014. Pflugers Arch. 466: 215-23. PMID: 24337823
- Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology. | Carrier, L., et al. 2015. Gene. 573: 188-97. PMID: 26358504
- Allelic imbalance and haploinsufficiency in MYBPC3-linked hypertrophic cardiomyopathy. | Glazier, AA., et al. 2019. Pflugers Arch. 471: 781-793. PMID: 30456444
- Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin. | Toepfer, CN., et al. 2019. Sci Transl Med. 11: PMID: 30674652
- Computational prediction of protein subdomain stability in MYBPC3 enables clinical risk stratification in hypertrophic cardiomyopathy and enhances variant interpretation. | Thompson, AD., et al. 2021. Genet Med. 23: 1281-1287. PMID: 33782553
- Slower Calcium Handling Balances Faster Cross-Bridge Cycling in Human MYBPC3 HCM. | Pioner, JM., et al. 2023. Circ Res. 132: 628-644. PMID: 36744470
- Long-Term Prevalence of Systolic Dysfunction in MYBPC3 Versus MYH7-Related Hypertrophic Cardiomyopathy. | Beltrami, M., et al. 2023. Circ Genom Precis Med. 16: 363-371. PMID: 37409452
- Novel MYBPC3 Mutations in Indian Population with Cardiomyopathies. | Rani, DS., et al. 2023. Pharmgenomics Pers Med. 16: 883-893. PMID: 37750083
- Hypertrophic cardiomyopathy in MYBPC3 carriers in aging. | Ananthamohan, K., et al. 2024. J Cardiovasc Aging. 4: PMID: 38406555
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MYBPC3 Antibody (F-1) | sc-137181 | 200 µg/ml | $322.00 | |||
MYBPC3 Antibody (F-1): m-IgGκ BP-HRP Bundle | sc-521444 | 200 µg Ab, 40 µg BP | $361.00 | |||
MYBPC3 Antibody (F-1): m-IgG1 BP-HRP Bundle | sc-533491 | 200 µg Ab; 20 µg BP | $361.00 | |||
MYBPC3 Antibody (F-1) AC | sc-137181 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MYBPC3 Antibody (F-1) HRP | sc-137181 HRP | 200 µg/ml | $322.00 | |||
MYBPC3 Antibody (F-1) FITC | sc-137181 FITC | 200 µg/ml | $336.00 | |||
MYBPC3 Antibody (F-1) PE | sc-137181 PE | 200 µg/ml | $349.00 | |||
MYBPC3 Antibody (F-1) Alexa Fluor® 488 | sc-137181 AF488 | 200 µg/ml | $364.00 | |||
MYBPC3 Antibody (F-1) Alexa Fluor® 546 | sc-137181 AF546 | 200 µg/ml | $364.00 | |||
MYBPC3 Antibody (F-1) Alexa Fluor® 594 | sc-137181 AF594 | 200 µg/ml | $364.00 | |||
MYBPC3 Antibody (F-1) Alexa Fluor® 647 | sc-137181 AF647 | 200 µg/ml | $364.00 | |||
MYBPC3 Antibody (F-1) Alexa Fluor® 680 | sc-137181 AF680 | 200 µg/ml | $364.00 | |||
MYBPC3 Antibody (F-1) Alexa Fluor® 790 | sc-137181 AF790 | 200 µg/ml | $364.00 |