MRP1 Antibody (QCRL-4): sc-18874
- MRP1 Antibody (QCRL-4) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against non-denatured membranes prepared from H69AR small cell lung cancer cell line of human origin
- recommended for detection of a conformational-dependent internal epitope of MRP1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See MRP1 (QCRL-1): sc-18835 for MRP1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MRP1 Antibody (QCRL-4) for WB and IHC(P) applications. These reagents are now offered in bundles with MRP1 Antibody (QCRL-4) (see ordering information below).
MRP1 Antibody (QCRL-4) is a mouse monoclonal IgG1 antibody that detects MRP1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and flow cytometry (FCM). MRP1, a member of the ATP-binding cassette (ABC) transporter family, plays a crucial role in conferring multidrug resistance in cancer cells by actively transporting a wide range of substrates, including chemotherapeutic agents, out of the cell. This function is particularly important as MRP1 can significantly impact the efficacy of cancer treatments, leading to treatment failure and disease progression. MRP1 is predominantly expressed in various tissues, including the brain, lungs, and testis, where MRP1 helps to regulate the intracellular concentration of potentially harmful compounds. MRP1′s localization in the cell membrane allows effective mediation of drug and xenobiotic efflux, thereby protecting cells from toxicity. Understanding the expression and function of MRP1 is vital for developing strategies to overcome drug resistance in cancer therapy, making anti-MRP1 antibody (QCRL-4) an essential tool for researchers studying multidrug resistance mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MRP1 Antibody (QCRL-4) References:
- Influences of glutathione on anionic substrate efflux in tumour cells expressing the multidrug resistance-associated protein, MRP1. | Bagrij, T., et al. 2001. Biochem Pharmacol. 62: 199-206. PMID: 11389878
- Expression of the multidrug resistance P glycoprotein (Pgp) and multidrug resistance associated protein (MRP1) in Down syndrome brains. | Engidawork, E., et al. 2001. J Neural Transm Suppl. 35-45. PMID: 11771758
- Cytoplasmic retraction of the amino terminus of human multidrug resistance protein 1. | Chen, Q., et al. 2002. Biochemistry. 41: 9052-62. PMID: 12119019
- MRP1 not MDR1 gene expression is the predominant mechanism of acquired multidrug resistance in two prostate carcinoma cell lines. | Zalcberg, J., et al. 2000. Prostate Cancer Prostatic Dis. 3: 66-75. PMID: 12497102
- The role of multidrug resistance protein 1 (MRP1) in transport of fluorescent anions across the human erythrocyte membrane. | Rychlik, B., et al. 2003. J Membr Biol. 193: 79-90. PMID: 12879156
- MYCN-mediated regulation of the MRP1 promoter in human neuroblastoma. | Manohar, CF., et al. 2004. Oncogene. 23: 753-62. PMID: 14737110
- Bilirubin protects astrocytes from its own toxicity by inducing up-regulation and translocation of multidrug resistance-associated protein 1 (Mrp1). | Gennuso, F., et al. 2004. Proc Natl Acad Sci U S A. 101: 2470-5. PMID: 14983033
- Expression of the multidrug resistance-associated protein 1 (MRP1) and the lung resistance-related protein (LRP) in human lung cancer. | Rybárová, S., et al. 2004. Neoplasma. 51: 169-74. PMID: 15254668
- CD40 stimulation induces vincristine resistance via AKT activation and MRP1 expression in a human multiple myeloma cell line. | Lee, SW., et al. 2012. Immunol Lett. 144: 41-8. PMID: 22445357
- Differential functional rescue of Lys(513) and Lys(516) processing mutants of MRP1 (ABCC1) by chemical chaperones reveals different domain-domain interactions of the transporter. | Iram, SH. and Cole, SP. 2014. Biochim Biophys Acta. 1838: 756-65. PMID: 24231430
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRP1 Antibody (QCRL-4) | sc-18874 | 200 µg/ml | $322.00 | |||
MRP1 Antibody (QCRL-4): m-IgG Fc BP-HRP Bundle | sc-536605 | 200 µg Ab; 10 µg BP | $361.00 | |||
MRP1 Antibody (QCRL-4): m-IgGκ BP-HRP Bundle | sc-533760 | 200 µg Ab; 40 µg BP | $361.00 | |||
MRP1 Antibody (QCRL-4): m-IgG1 BP-HRP Bundle | sc-544701 | 200 µg Ab; 20 µg BP | $361.00 | |||
MRP1 Antibody (QCRL-4) FITC | sc-18874 FITC | 200 µg/ml | $336.00 | |||
MRP1 Antibody (QCRL-4) PE | sc-18874 PE | 200 µg/ml | $349.00 |