Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Lck-interacting molecule (LIME) is a 295 amino acid transmembrane adaptor protein primarily expressed in hematopoietic and lung cells. LIME has a short extracellular domain and a cytoplasmic tail containing five tyrosine-based motifs. LIME becomes tyrosine-phosphorylated after the CD4 or CD8 co-receptors cross-link. The phosphorylated LIME interacts with Lck, the Src fam-ily kinase, and Csk, its negative regulator. LIME is expressed during the early and late stages of T cell activation and appears to be involved in regulation of T cell activation by co-receptors. It may be involved in activation of the ERK and JNK (both are part of the mitogen-activated protein kinase family) pathways in T cells. BCR-mediated B cell activation may also involve LIME.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.