VIP Activators
Common VIP Activators include, but are not limited to Retinoic Acid, all trans CAS 302-79-4, Forskolin CAS 66575-29-9, Progesterone CAS 57-83-0, β-Estradiol CAS 50-28-2 and Dexamethasone CAS 50-02-2.
VIP activators are compounds designed to stimulate the activity or enhance the effects of VIP (Vasoactive Intestinal Peptide). VIP is a 28-amino acid neuropeptide that belongs to a family of structurally similar peptides, including glucagon, secretin, and growth hormone-releasing factor. It is widely distributed throughout the body, with pronounced presence in the gastrointestinal system, the central and peripheral nervous systems, and the cardiovascular system. In these regions, VIP exerts a multitude of biological actions. For instance, in the gastrointestinal system, VIP plays roles in smooth muscle relaxation, stimulation of water and electrolyte secretion, and modulation of local blood flow. In the nervous system, VIP acts as a neurotransmitter and neuromodulator, influencing various neural processes.
The effects of VIP are mediated primarily through its interaction with specific G-protein coupled receptors, known as VPAC1 and VPAC2. Upon binding to these receptors, VIP can activate intracellular signaling cascades, leading to diverse cellular responses such as increased cyclic AMP production, calcium mobilization, and activation of specific kinases. VIP activators, by enhancing the peptide's activity or its interaction with its receptors, amplify the physiological responses associated with VIP signaling. These activators can be instrumental in understanding the multifaceted roles of VIP in various physiological contexts, ranging from neural communication to vascular tone modulation. The molecular mechanisms of action, specificity, and broader cellular effects of VIP activators offer a rich area of exploration, shedding light on the intricate regulatory networks that VIP is involved in and the modulatory effects of external compounds on these pathways.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid regulates gene expression by activating retinoic acid receptors. It might modulate VIP expression in certain neural and immune cell types. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels, which can induce VIP expression in certain cell types. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone can modulate VIP expression in certain tissues, especially during pregnancy. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estrogen can regulate VIP expression, especially in reproductive tissues and the central nervous system. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
As a glucocorticoid, dexamethasone can modulate the expression of various genes, including VIP, particularly in immune cells. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine activates VIP expression in the central nervous system and the gut, depending on the context. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 can influence VIP expression, especially in immune and neural cells, through the activation of its receptors. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $31.00 $61.00 $219.00 $352.00 | 2 | |
L-Arginine is a precursor for nitric oxide (NO) synthesis, and NO can modulate VIP expression in certain cell types. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
As a second messenger, cAMP can influence the transcription of several genes, including VIP, in various tissues. | ||||||