SLC17A2 inhibitors are a class of chemical compounds that specifically target and inhibit the function of the SLC17A2 protein, a member of the solute carrier family. SLC17A2 is part of the larger SLC17 family, which is known for its role in transporting organic anions, including neurotransmitters and other small molecules, across cellular membranes. The inhibition of SLC17A2 can disrupt the transport processes it mediates, offering researchers a powerful tool to study the protein's function and its broader impact on cellular activities. By selectively inhibiting SLC17A2, scientists can explore how this transporter influences the distribution and concentration of specific anions within cells, and how these changes affect cellular metabolism and signaling.
The use of SLC17A2 inhibitors in research is particularly valuable for dissecting the role of this transporter in various biological systems. By blocking SLC17A2 activity, researchers can observe the resulting alterations in cellular processes, such as changes in ion gradients, neurotransmitter release, and intracellular signaling pathways. These studies help to elucidate the specific substrates transported by SLC17A2 and the physiological contexts in which this transporter is most active. Additionally, SLC17A2 inhibitors can be used to explore the regulatory mechanisms that control the expression and activity of this protein, providing insights into how cells maintain homeostasis in response to environmental and intracellular cues. Through these investigations, SLC17A2 inhibitors contribute to a deeper understanding of membrane transport mechanisms and the complex interplay between transport proteins and cellular function.
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| 製品名 | CAS # | カタログ # | 数量 | 価格 | 引用文献 | レーティング |
|---|---|---|---|---|---|---|
D(−)-2-Amino-5-phosphonovaleric acid (D-AP5) | 79055-68-8 | sc-200434 | 5 mg | $95.00 | 2 | |
NMDA受容体拮抗薬であるAP5は、間接的にグルタミン酸シグナル伝達および放出に影響を与える可能性がある。 | ||||||
6-Cyano-7-nitroquinoxaline-2,3-dione | 115066-14-3 | sc-505104 | 10 mg | $204.00 | 2 | |
CNQXは強力なAMPA受容体拮抗薬であり、間接的にグルタミン酸シグナル伝達および放出に影響を与える可能性がある。 | ||||||
Kynurenic acid | 492-27-3 | sc-202683 sc-202683A sc-202683B | 250 mg 1 g 5 g | $25.00 $56.00 $135.00 | 6 | |
これは興奮性アミノ酸受容体の広域スペクトル拮抗薬であり、グルタミン酸シグナル伝達を減少させる。 | ||||||
Riluzole | 1744-22-5 | sc-201081 sc-201081A sc-201081B sc-201081C | 20 mg 100 mg 1 g 25 g | $20.00 $189.00 $209.00 $311.00 | 1 | |
リルゾールはグルタミン酸の放出を阻害し、SLC17A7の機能を間接的に影響する。 | ||||||
Ethosuximide | 77-67-8 | sc-211431 | 1 g | $300.00 | ||
この化合物はT型カルシウムチャネルの活性を低下させ、グルタミン酸放出に間接的に影響する。 | ||||||
Lamotrigine | 84057-84-1 | sc-201079 sc-201079A | 10 mg 50 mg | $118.00 $476.00 | 1 | |
ラモトリギンは電位感受性ナトリウムチャネルを阻害し、グルタミン酸放出の減少につながる。 | ||||||
Topiramate | 97240-79-4 | sc-204350 sc-204350A | 10 mg 50 mg | $105.00 $362.00 | ||
GABA誘発電流を調節し、間接的にグルタミン酸放出に影響を与える。 | ||||||
Felbamate | 25451-15-4 | sc-203579 sc-203579A | 10 mg 50 mg | $101.00 $373.00 | ||
フェルバメートはNMDA受容体拮抗薬として作用し、間接的にグルタミン酸シグナル伝達と放出に影響を与える。 | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
プロトンフォアはプロトン勾配を崩壊させ、SLC17Aの機能を間接的に影響させる可能性がある。 | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $31.00 | 3 | |
非ステロイド系抗炎症薬であり、間接的にSLC17Aのようなイオンチャネルやトランスポーターに影響を与える可能性がある。 | ||||||