caspase-9 Antibody (9CSP03): sc-73548
- caspase-9 Antibody (9CSP03) is a mouse monoclonal IgG1 κ, cited in 32 publications, provided at 200 µg/ml
- raised against the prodomain of caspase-9 of human origin
- recommended for detection of caspase-9 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See caspase-9 (96.1.23): sc-56076 for caspase-9 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for caspase-9 Antibody (9CSP03) for WB and IHC(P) applications. These reagents are now offered in bundles with caspase-9 Antibody (9CSP03) (see ordering information below).
QUICK LINKS
SEE ALSO...
caspase-9 Antibody (9CSP03) is a mouse monoclonal IgG1 antibody that detects caspase-9 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Caspase-9 plays a pivotal role in the intrinsic pathway of apoptosis, acting as an initiator caspase that is activated in response to cellular stress and mitochondrial dysfunction. Upon activation, caspase-9 cleaves and activates downstream effector caspases, such as caspase-3 and caspase-7, leading to the execution phase of apoptosis, which is crucial for maintaining cellular homeostasis and eliminating damaged or unwanted cells. Proper regulation of caspase-9 is essential, as dysregulation can contribute to various diseases, including cancer, where evasion of apoptosis allows for uncontrolled cell proliferation. Caspase-9 is primarily located in the cytosol and translocates to the mitochondria upon activation, highlighting its importance in the cellular response to stress signals. The ability of caspase-9 to integrate signals from both intrinsic and extrinsic pathways underscores its significance in therapeutic strategies aimed at modulating apoptosis in disease contexts. Anti-caspase-9 antibody (9CSP03) is an invaluable tool for researchers studying apoptosis and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
caspase-9 Antibody (9CSP03) References:
- Caspase-9 can be activated without proteolytic processing. | Stennicke, HR., et al. 1999. J Biol Chem. 274: 8359-62. PMID: 10085063
- Caspase-9 processing by caspase-3 via a feedback amplification loop in vivo. | Fujita, E., et al. 2001. Cell Death Differ. 8: 335-44. PMID: 11550085
- Caspase-8 and Apaf-1-independent caspase-9 activation in Sendai virus-infected cells. | Bitzer, M., et al. 2002. J Biol Chem. 277: 29817-24. PMID: 12021264
- Caspase-3 and caspase-9 mediate developmental apoptosis in the mouse olfactory system. | Cowan, CM. and Roskams, AJ. 2004. J Comp Neurol. 474: 136-48. PMID: 15156583
- Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation. | Chao, Y., et al. 2005. PLoS Biol. 3: e183. PMID: 15941357
- Caspase-9 pathway activation by inhibiting endogenous fibroblast growth factor signaling in human glioma cells. | Fukushima, S., et al. 2008. Int J Oncol. 32: 467-73. PMID: 18202770
- Caspase-9 activation revealed by semaphorin 7A cleavage is independent of apoptosis in the aged olfactory bulb. | Ohsawa, S., et al. 2009. J Neurosci. 29: 11385-92. PMID: 19741144
- ATM kinase promotes both caspase-8 and caspase-9 activation during TNF-α-induced apoptosis of HeLa cells. | Liu, L., et al. 2014. FEBS Lett. 588: 929-35. PMID: 24530529
- Activation of Bcl-2-Caspase-9 Apoptosis Pathway in the Testis of Asthmatic Mice. | Xu, W., et al. 2016. PLoS One. 11: e0149353. PMID: 26938720
- Linalool attenuated ischemic injury in PC12 cells through inhibition of caspase-3 and caspase-9 during apoptosis. | Hosseini, A., et al. 2023. Food Sci Nutr. 11: 249-260. PMID: 36655091
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-9 Antibody (9CSP03) | sc-73548 | 200 µg/ml | $322.00 | |||
caspase-9 Antibody (9CSP03): m-IgG Fc BP-HRP Bundle | sc-537222 | 200 µg Ab; 10 µg BP | $361.00 | |||
caspase-9 Antibody (9CSP03): m-IgGκ BP-HRP Bundle | sc-534435 | 200 µg Ab; 40 µg BP | $361.00 | |||
caspase-9 Antibody (9CSP03): m-IgG1 BP-HRP Bundle | sc-545088 | 200 µg Ab; 20 µg BP | $361.00 |