caspase-9 Antibody (4i31): sc-70507
- caspase-9 Antibody (4i31) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- raised against full length caspase-9 of human origin
- recommended for detection of caspase-9 of human origin by WB and IP
- See caspase-9 (96.1.23): sc-56076 for caspase-9 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for caspase-9 Antibody (4i31) for WB applications. These reagents are now offered in bundles with caspase-9 Antibody (4i31) (see ordering information below).
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caspase-9 Antibody (4i31) is a mouse monoclonal IgG1 antibody that detects caspase-9 in human samples through western blotting (WB) and immunoprecipitation (IP) applications. Caspase-9 plays a pivotal role in the intrinsic pathway of apoptosis, acting as an initiator caspase that is crucial for the activation of downstream effector caspases, such as caspase-3 and caspase-7. This activation is essential for the execution of programmed cell death, a process vital for maintaining cellular homeostasis and eliminating damaged or unwanted cells. Proper functioning of caspase-9 is particularly important in cancer, where dysregulation of apoptosis can lead to tumorigenesis and resistance to therapy. Caspase-9 is located in the cytosol and activates in response to apoptotic signals, such as mitochondrial outer membrane permeabilization, highlighting its role as a key regulator in cellular response to stress and damage. The ability of caspase-9 to cleave and activate other caspases underscores its importance in the apoptotic cascade, making caspase-9 a critical target for research in cancer biology and therapeutic development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
caspase-9 Antibody (4i31) References:
- Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis. | Lee, HJ., et al. 2008. Cancer Lett. 270: 342-53. PMID: 18617322
- Promotion of Caspase Activation by Caspase-9-mediated Feedback Amplification of Mitochondrial Damage. | Guerrero, AD., et al. 2012. J Clin Cell Immunol. 3: PMID: 23539542
- Phosphorylation status of Akt and caspase-9 in gastric and colorectal carcinomas. | Sangawa, A., et al. 2014. Int J Clin Exp Pathol. 7: 3312-7. PMID: 25031754
- Phosphorylation of caspase-9 at Thr125 directs paclitaxel resistance in ovarian cancer. | Byun, MR. and Choi, JW. 2018. Oncotarget. 9: 1041-1047. PMID: 29416675
- CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis. | An, HK., et al. 2020. Autophagy. 16: 1598-1617. PMID: 31818185
- Antitumor activity of ginsenoside Rd in gastric cancer via up-regulation of Caspase-3 and Caspase-9. | Tian, YZ., et al. 2020. Pharmazie. 75: 147-150. PMID: 32295691
- LINC01980 stimulates the progression of hepatocellular carcinoma via downregulating caspase 9. | Zang, Y., et al. 2020. J BUON. 25: 1395-1403. PMID: 32862582
- Molecular docking data of piperine with Bax, Caspase 3, Cox 2 and Caspase 9. | Kirubhanand, C., et al. 2020. Bioinformation. 16: 458-461. PMID: 32884209
- HSP27 Inhibitory Activity against Caspase-3 Cleavage and Activation by Caspase-9 Is Enhanced by Chaperone O-GlcNAc Modification in Vitro. | Wang, B., et al. 2023. ACS Chem Biol. 18: 1698-1704. PMID: 37450938
- Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes. | Yadav, PS., et al. 2023. iScience. 26: 107548. PMID: 37636062
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
caspase-9 Antibody (4i31) | sc-70507 | 200 µg/ml | $322.00 | |||
caspase-9 Antibody (4i31): m-IgG Fc BP-HRP Bundle | sc-539287 | 200 µg Ab; 10 µg BP | $361.00 | |||
caspase-9 Antibody (4i31): m-IgG1 BP-HRP Bundle | sc-541379 | 200 µg Ab; 20 µg BP | $361.00 |