TREX-1 Activators
The chemical class of TREX-1 activators constitutes a multifaceted array of compounds, each with unique mechanisms shaping TREX-1 activation through nuanced modulation of diverse cellular pathways. An exemplar within this class, Nordihydroguaiaretic acid (NDGA), operates by indirect activation of TREX-1 through inhibition of the NF-κB pathway. Given that NF-κB acts as a negative regulator of TREX-1, NDGA's intervention effectively alleviates this inhibition, resulting in augmented TREX-1 activation. In a distinct modulatory approach, Resveratrol emerges as another activator, influencing TREX-1 indirectly by orchestrating the SIRT1 pathway. Serving as a SIRT1 activator, Resveratrol enhances the deacetylation of p53, a positive regulator of TREX-1 expression. This intricate interplay presents a unique mechanism for TREX-1 activation, expanding the repertoire of pathways involved.
The chemical class further encompasses a spectrum of compounds such as 6-Mercaptopurine, Ciclopirox olamine, Quinacrine, Piperlongumine, Mefloquine, Digoxin, Berberine, Metformin, Bortezomib, and Chloroquine. Each of these compounds exerts its influence on specific pathways, indirectly activating TREX-1. This diversity not only furnishes researchers with a comprehensive toolkit for precise modulation of TREX-1 but also underscores the complex and interconnected nature of cellular pathways involved in TREX-1 activation. 6-Mercaptopurine, for instance, impacts nucleotide metabolism, influencing TREX-1 activation. Ciclopirox olamine, a known antifungal, demonstrates its indirect impact on TREX-1 through distinct cellular pathways. Similarly, the array of compounds within this class showcases a rich tapestry of interactions, collectively contributing to the nuanced regulation of TREX-1. In summary, the intricate modulation of TREX-1 by this chemical class reflects a sophisticated dance of molecular interactions, unveiling the interconnectedness of various cellular pathways in shaping TREX-1 activation. This expansive toolkit not only enhances our understanding of TREX-1 regulation but also provides valuable insights for researchers exploring the broader landscape of cellular processes influenced by these chemical modulators.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $109.00 $384.00 $2190.00 | 3 | |
NDGA is a potent inhibitor of the NF-κB pathway, exerting its influence through the inhibition of IKK activity. By impeding NF-κB signaling, NDGA indirectly activates TREX-1, as NF-κB negatively regulates TREX-1 expression, and its inhibition relieves this constraint. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenolic compound, indirectly activates TREX-1 by modulating the SIRT1 pathway. Acting as a SIRT1 activator, resveratrol enhances SIRT1-mediated deacetylation of p53. Deacetylated p53 positively regulates TREX-1 expression, providing an indirect mechanism for the activation of TREX-1. | ||||||
6-Mercaptopurine | 50-44-2 | sc-361087 sc-361087A | 50 mg 100 mg | $72.00 $104.00 | ||
As an immunosuppressive agent, 6-Mercaptopurine indirectly activates TREX-1 by influencing the purine metabolism pathway. By inhibiting key enzymes in purine synthesis, it leads to the accumulation of endogenous nucleotides, triggering the cGAS-STING pathway. The resultant cGAS-STING activation positively regulates TREX-1 expression. | ||||||
Ciclopirox | 29342-05-0 | sc-217893 | 25 mg | $207.00 | 2 | |
Ciclopirox olamine indirectly activates TREX-1 by targeting the AMPK pathway. Through AMPK activation, Ciclopirox olamine modulates cellular energy status, leading to downstream effects on p53. Activated p53 positively regulates TREX-1 expression, establishing an indirect link between Ciclopirox olamine and TREX-1 activation. | ||||||
Quinacrine, Dihydrochloride | 69-05-6 | sc-204222 sc-204222B sc-204222A sc-204222C sc-204222D | 100 mg 1 g 5 g 200 g 300 g | $46.00 $57.00 $87.00 $3257.00 $4821.00 | 4 | |
Quinacrine indirectly activates TREX-1 through the modulation of autophagy. By inhibiting lysosomal function, Quinacrine disrupts the autophagic flux, leading to the accumulation of damaged DNA. This activates the cGAS-STING pathway, which positively regulates TREX-1 expression, establishing an indirect mechanism for TREX-1 activation. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine indirectly activates TREX-1 by targeting the NRF2 pathway. Through NRF2 activation, Piperlongumine upregulates the expression of antioxidants, leading to the attenuation of oxidative stress. Reduced oxidative stress positively regulates TREX-1 expression, establishing an indirect link between Piperlongumine and TREX-1 activation. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $143.00 $694.00 | ||
12β-Hydroxydigitoxin (Digoxin) indirectly activates TREX-1 by influencing the calcium signaling pathway. By inhibiting the Na+/K+-ATPase pump, Digoxin increases intracellular calcium levels, leading to the activation of the cGAS-STING pathway. Activated cGAS-STING positively regulates TREX-1 expression, establishing an indirect link between Digoxin and TREX-1 activation. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine indirectly activates TREX-1 by targeting the SIRT1 pathway. As a SIRT1 activator, Berberine enhances the deacetylation of p53. Deacetylated p53 positively regulates TREX-1 expression, providing an indirect mechanism for the activation of TREX-1. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin indirectly activates TREX-1 through the modulation of the AMPK pathway. AMPK activation by Metformin influences cellular energy homeostasis, leading to downstream effects on p53. Activated p53 positively regulates TREX-1 expression, establishing an indirect link between Metformin and TREX-1 activation. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib indirectly activates TREX-1 by targeting the NF-κB pathway. Through the inhibition of the proteasome, Bortezomib disrupts NF-κB signaling, relieving its negative regulation on TREX-1 expression. This establishes an indirect mechanism for TREX-1 activation by Bortezomib. | ||||||