POFUT2 Activators
POFUT2 activators are compounds that interact with the protein O-fucosyltransferase 2, commonly abbreviated as POFUT2. This enzyme is part of a specific subset of glycosyltransferases that catalyze the transfer of fucose, a hexose deoxy sugar, to oxygen on serine or threonine residues in epidermal growth factor-like (EGF-like) repeats or thrombospondin type 1 repeats (TSRs) present in various proteins. The activity of POFUT2 is crucial for the proper folding and function of these proteins, which contain the EGF-like sequences or TSRs. The process of O-fucosylation, mediated by POFUT2, influences the biological activity of these proteins, impacting a range of cellular processes. POFUT2 activators, therefore, are chemicals that enhance the enzymatic action of POFUT2, increasing the level of protein fucosylation within cells.
The biological role of POFUT2 is complex, as it is involved in various cellular pathways, including cell signaling and development. The fucosylation modification added by POFUT2 can affect molecular interactions, protein stability, and cell communication. By increasing the activity of POFUT2, its activators can lead to an increase in the modified proteins that are correctly folded and functional, thereby influencing the cellular pathways where these proteins are key components. The specific mechanisms by which POFUT2 activators exert their effects can involve allosteric modulation of the enzyme or stabilization of its active form, but the exact processes can vary depending on the molecular structure of the activators.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
L-Ascorbic acid is a cofactor for many enzymes, including prolyl and lysyl hydroxylases, which are involved in the post-translational modifications preceding O-fucosylation by POFUT2. By promoting these activities, L-Ascorbic acid indirectly supports POFUT2-mediated O-fucosylation of Notch receptors. | ||||||
Sodium selenate | 13410-01-0 | sc-251052A sc-251052 sc-251052B sc-251052C | 25 g 100 g 500 g 1 kg | $52.00 $187.00 $332.00 $599.00 | ||
Selenium compounds like sodium selenate can activate the antioxidant response element (ARE) signaling pathway. This pathway can enhance the expression of various enzymes and proteins that may include those in the O-fucosylation process, thereby potentially increasing POFUT2 activity indirectly. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper ions are cofactors for numerous enzymes, including some that participate in the Notch signaling pathway. By supplying copper ions, Copper(II) sulfate could enhance the activity of these enzymes, thereby potentially increasing the functional activity of POFUT2. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN, a precursor of NAD+, can increase cellular NAD+ levels, which is associated with enhanced metabolism and sirtuin function. Sirtuins can modulate the activity of various cellular processes, including those that might interact with Notch signaling and O-fucosylation, indirectly influencing POFUT2. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, which increases the levels of cAMP. Elevated cAMP can lead to the activation of protein kinase A (PKA) which may influence gene expression and protein modification processes, potentially enhancing the environment for POFUT2 activity in O-fucosylation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a catechin found in green tea, is known for its antioxidant properties and has been shown to modulate various signaling pathways, including Notch signaling. By influencing this pathway, EGCG may increase the activity of POFUT2 by upregulating the processing of Notch receptors. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that can elevate intracellular cAMP levels, potentially enhancing PKA activity. This can lead to the phosphorylation of proteins that interact with the Notch signaling pathway, thereby indirectly promoting the activity of POFUT2. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $57.00 $607.00 $176.00 | ||
Spermidine has been associated with various cellular processes including autophagy and can modulate signaling pathways. Through its role in cellular homeostasis, spermidine may affect the Notch pathway and subsequently the enzymatic function of POFUT2. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions are critical for many enzymes and may influence signal transduction pathways including those related to Notch signaling. By providing zinc, Zinc sulfate could enhance the activity of POFUT2 indirectly by increasing the activity of enzymes that work upstream of POFUT2. | ||||||