PGBD5 Activators
PGBD5, or PiggyBac Transposable Element Derived 5, is a protein that is encoded by the PGBD5 gene in humans. As its name suggests, it's related to the piggyBac family of transposable elements, which are sequences of DNA that can move or "jump" to different positions within the genome.PGBD5 is unique because it's a domesticated transposase, meaning it's found in a transposable element that has been incorporated into the host genome and repurposed for a cellular function. This is a relatively rare event in evolution.
The specific function of PGBD5 is not completely understood. However, it's been associated with DNA repair and has been found to be overexpressed in certain types of cancers, including neuroblastoma and medulloblastoma. There's evidence that PGBD5 may contribute to genomic instability and tumorigenesis, possibly by inducing DNA rearrangements.
PGBD5 has been proposed as a biomarker for certain pediatric cancers, and it's an active area of research in cancer biology. Understanding the role of PGBD5 in tumorigenesis could provide insights into the mechanisms of cancer development and progression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib is a PARP inhibitor, which indirectly influences DNA repair mechanisms. By inhibiting PARP, it may alter the cellular environment in a way that affects PGBD5 activity. | ||||||
Veliparib | 912444-00-9 | sc-394457A sc-394457 sc-394457B | 5 mg 10 mg 50 mg | $182.00 $275.00 $726.00 | 3 | |
Veliparib is another PARP inhibitor. Its role in DNA repair could have an indirect effect on PGBD5, particularly in the context of DNA damage response. | ||||||
Rucaparib | 283173-50-2 | sc-507419 | 5 mg | $150.00 | ||
Rucaparib, also a PARP inhibitor, could impact PGBD5 activity by modulating DNA repair pathways and genomic stability. | ||||||
Talazoparib | 1207456-01-6 | sc-507440 | 10 mg | $795.00 | ||
As a potent PARP inhibitor, Talazoparib might influence PGBD5 through its role in DNA damage and repair. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C is an alkylating agent that forms DNA crosslinks, thus potentially influencing PGBD5 activity by inducing DNA damage and repair responses. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide interferes with DNA topoisomerase II, affecting DNA repair and replication, which could indirectly modulate PGBD5. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms DNA adducts leading to DNA damage. This could indirectly influence PGBD5 activity in DNA repair pathways. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin, a topoisomerase I inhibitor, impacts DNA replication and repair, potentially affecting PGBD5 indirectly. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Bleomycin causes DNA strand breaks, potentially impacting PGBD5 activity in the DNA damage response. | ||||||
Carboplatin | 41575-94-4 | sc-202093 sc-202093A | 25 mg 100 mg | $48.00 $135.00 | 14 | |
Carboplatin, similar to cisplatin, forms DNA adducts and may indirectly affect PGBD5 through its role in DNA repair. | ||||||