PDPR Activators
PDPR Activators consist of chemicals known to facilitate the operation of pyruvate dehydrogenase phosphatase and the pyruvate dehydrogenase complex, either directly or indirectly. These chemicals do not inhibit PDPR but rather necessitate or complement its activity. Compounds such as Coenzyme A and NAD+ specifically act to increase the rate or efficiency of the PDC, which in turn would require PDPR's regulatory influence. Calcium Chloride and Alpha-Ketoglutarate are unique in that they serve as cofactors or substrates within the cellular pathways linked to PDPR, thereby naturally creating a need for PDPR's unique modulatory action.
Other activators like Dichloroacetate (DCA) or Isoproterenol function through a more convoluted route. DCA inhibits PDK, the kinase that phosphorylates and inactivates PDC. The inhibition of PDK leads to an activation of PDC, thereby requiring PDPR for its regulatory action. Isoproterenol works by activating the cAMP pathway which can indirectly influence the activity of PDC, creating an environment where PDPR's role becomes crucial. All these chemicals can, therefore, be understood as serving a role in the upregulation of PDPR's modulatory functions.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Coenzyme A | 85-61-0 anhydrous | sc-211123 sc-211123A sc-211123B sc-211123C | 10 mg 25 mg 100 mg 250 mg | $83.00 $135.00 $418.00 $801.00 | 1 | |
Increases availability of acetyl-CoA, driving the pyruvate dehydrogenase complex (PDC) forward, thereby necessitating the activity of PDPR to modulate PDP and PDC. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
Enhances PDC activity by acting as an electron acceptor, thus indirectly activating PDPR for the reactivation and dephosphorylation of PDC. | ||||||
Adenosine phosphate(Vitamin B8) | 61-19-8 | sc-278678 sc-278678A | 50 g 100 g | $160.00 $240.00 | ||
Elevates AMP levels, triggering AMPK pathway, which can positively influence PDC and therefore PDPR. | ||||||
Sodium dichloroacetate | 2156-56-1 | sc-203275 sc-203275A | 10 g 50 g | $55.00 $209.00 | 6 | |
Directly stimulates PDC by inhibiting pyruvate dehydrogenase kinases (PDK), resulting in a demand for PDPR's regulatory action. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
Facilitates transport of acetyl groups to mitochondria, encouraging PDC activity and thereby necessitating PDPR action. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Acts as a cofactor for PDP, potentially increasing its sensitivity and thus the need for PDPR to modulate its activity. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
Drives TCA cycle forward, leading to enhanced PDC activity and thereby an increased role for PDPR. | ||||||
Citric Acid, Anhydrous | 77-92-9 | sc-211113 sc-211113A sc-211113B sc-211113C sc-211113D | 500 g 1 kg 5 kg 10 kg 25 kg | $50.00 $110.00 $145.00 $248.00 $598.00 | 1 | |
Drives the TCA cycle and leads to accumulation of acetyl-CoA, thus promoting PDC activity and subsequent demand for PDPR activity. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $38.00 $198.00 $65.00 | 5 | |
Increases cellular glycolysis rate, thereby feeding more pyruvate into PDC and necessitating PDPR's activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Activates cAMP pathway which can influence PDC activity through phosphorylation/dephosphorylation, increasing the need for PDPR. | ||||||