N-α-Benzoyl-L-arginine-4-nitranilide Activators
N-α-Benzoyl-L-arginine-4-nitranilide encompass a variety of chemical compounds that directly bind to and enhance the functional activity of the Glucocorticoid Receptor (GR), encoded by the NR3C1 gene. Physiological ligands such as cortisol, and synthetic glucocorticoids like dexamethasone and prednisolone, act as agonists that induce a conformational change in the receptor, which facilitates its dissociation from chaperone proteins and subsequent translocation into the nucleus. Once in the nucleus, the Glucocorticoid Receptor binds to specific DNA sequences known as glucocorticoid response elements (GREs), initiating or repressing the transcription of target genes that regulate various physiological processes, including metabolism, immune responses, and inflammation. The potency of these activators, such as betamethasone and hydrocortisone, lies in their ability to modulate gene expression with high specificity, thereby controlling the intensity and duration of the cellular responses to stress, infection, and other stimuli.
Additional synthetic glucocorticoids, including triamcinolone acetonide, fluticasone propionate, and mometasone furoate, serve to further enhance the activity of the Glucocorticoid Receptor by binding with varying affinities and activating the receptor's downstream signaling pathways.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine binds to its receptors and activates phospholipase C, resulting in the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). This signaling cascade elevates intracellular calcium, which may indirectly enhance the activity of N-α-Benzoyl-L-arginine-4-nitranilide by promoting proteolytic cleavage. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $530.00 | 3 | |
Serotonin, through its receptors, activates adenylate cyclase, increasing cAMP levels. Increased cAMP can activate protein kinase A (PKA), which could enhance the activity of N-α-Benzoyl-L-arginine-4-nitranilide by modifying the environment in which it operates. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin, via its B2 receptor, activates phospholipase C, leading to increased IP3 and DAG, and subsequently elevated calcium levels. This enhancement of calcium signaling could indirectly increase the activity of N-α-Benzoyl-L-arginine-4-nitranilide by influencing protease activity. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can bind to D1-like receptors, stimulating adenylate cyclase and increasing cAMP levels. cAMP activates PKA, potentially enhancing the cleavage efficiency of N-α-Benzoyl-L-arginine-4-nitranilide. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, through beta-adrenergic receptors, can increase adenylate cyclase activity, thus raising cAMP levels. The subsequent activation of PKA may indirectly enhance the hydrolysis of N-α-Benzoyl-L-arginine-4-nitranilide. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $326.00 $485.00 | 3 | |
Norepinephrine, via beta-adrenergic receptors, increases cAMP levels, activating PKA. This can lead to a cascade of phosphorylation events, potentially increasing the activity of N-α-Benzoyl-L-arginine-4-nitranilide. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that raises intracellular cAMP levels, thereby activating PKA. This could lead to enhanced activity of N-α-Benzoyl-L-arginine-4-nitranilide by promoting a favorable environment for its proteolytic action. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylate cyclase, leading to increased cAMP levels and PKA activation. This could indirectly enhance the cleavage activity of N-α-Benzoyl-L-arginine-4-nitranilide by altering the cellular environment. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which can influence numerous cellular pathways and may enhance the activity of N-α-Benzoyl-L-arginine-4-nitranilide by favoring protease activation. | ||||||