Mat1 Activators
Chemicals that can activate Mat1, or CDK-activating kinase assembly factor MAT1, fall into a unique class characterized by their influence on cellular processes and biochemical pathways indirectly related to Mat1's function. These compounds, primarily inhibitors of various enzymes or processes crucial for cell cycle progression and DNA synthesis, exert their effects by modulating the cellular environment in which Mat1 operates.
Most of these chemicals are inhibitors of processes like DNA replication, microtubule formation, and protein synthesis. For example, inhibitors of DNA topoisomerases like Camptothecin and Etoposide induce DNA damage, which can influence the activation of CDKs and, in turn, affect Mat1. Similarly, compounds that affect microtubule dynamics, such as Paclitaxel and Nocodazole, disrupt cell cycle progression at the mitotic phase, thereby impacting CDK activation and potentially influencing Mat1 activity. Other compounds like Cycloheximide and Olivomycin, which interfere with protein and RNA synthesis, create a cellular context that requires adjustment in CDK activity, again potentially influencing Mat1.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Inhibits protein synthesis in eukaryotic cells, impacting cell cycle progression and potentially influencing the activity of Mat1 as part of the cell cycle regulatory mechanism. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Inhibits DNA topoisomerase I, causing DNA damage. This can influence the pathways involving CDK activation and potentially impact Mat1 activity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Acts as a DNA topoisomerase II inhibitor, causing DNA strand breaks. This can lead to changes in the cellular DNA damage response pathways, indirectly affecting CDK activation and potentially influencing Mat1 activity. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules and prevents their disassembly, affecting cell cycle progression at the mitotic phase, which indirectly influences CDK activation and potentially impacts Mat1 activity. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
A pyrimidine analog that interferes with DNA synthesis. By impacting DNA replication, it can indirectly affect CDK activation, and hence Mat1 activity. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Disrupts microtubule formation in mitosis, potentially affecting the activation of CDKs involved in cell cycle progression and indirectly influencing Mat1 activity. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
A purine analogue that inhibits CDKs, including those in the CAK complex, potentially influencing Mat1 activity indirectly. | ||||||
Purvalanol B | 212844-54-7 | sc-361300 sc-361300A | 10 mg 50 mg | $199.00 $846.00 | ||
Another CDK inhibitor, which can indirectly influence the activity of CAK and Mat1 by altering the cell cycle progression. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Disrupts microtubule polymerization, affecting cell cycle progression, potentially influencing CAK and Mat1. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Cross-links DNA, leading to cell cycle arrest and potentially impacting CAK and Mat1 indirectly through DNA damage response pathways. | ||||||