Date published: 2026-5-30

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Mat1 Inhibitors

Mat1 inhibitors belong to a specific class of compounds designed to modulate the activity of Mat1, a protein that plays a critical role in cell cycle progression and the regulation of DNA replication. These inhibitors are meticulously developed to interact with Mat1, affecting its function in coordinating the transition between different phases of the cell cycle. Mat1 is known to be associated with cellular processes such as DNA synthesis and the regulation of checkpoint mechanisms. By selectively engaging with Mat1, these inhibitors aim to influence cell cycle dynamics, DNA replication, and cell proliferation. Mat1 inhibitors can encompass a range of chemical structures, including small molecules or peptides, designed to effectively bind to Mat1's functional domains.

The primary purpose of developing Mat1 inhibitors is to investigate the intricate mechanisms by which Mat1 contributes to cell cycle progression and DNA replication. By modulating Mat1 activity, researchers can gain insights into how this protein orchestrates the precise timing of DNA synthesis and coordinates cell division. These inhibitors serve as essential tools for exploring the molecular events that govern cell cycle transitions and DNA replication checkpoints.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Sinefungin

58944-73-3sc-203263
sc-203263B
sc-203263C
sc-203263A
1 mg
100 mg
1 g
10 mg
$271.00
$5202.00
$40368.00
$704.00
4
(1)

Sinefungin is a natural nucleoside analog and a well-known inhibitor of MATIt resembles the structure of SAMe and competes with it for binding to the enzyme's active site.

Indole-3-carbinol

700-06-1sc-202662
sc-202662A
sc-202662B
sc-202662C
sc-202662D
1 g
5 g
100 g
250 g
1 kg
$39.00
$61.00
$146.00
$312.00
$1032.00
5
(1)

I3C is a phytochemical found in cruciferous vegetables and has been identified as a MAT1 inhibitor.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

EGCG, a major polyphenol in green tea, has been suggested to inhibit MAT1 activity.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin, a bioactive compound found in turmeric, has shown inhibitory effects on MAT1 in certain studies.

5′-Deoxy-5′-methylthioadenosine

2457-80-9sc-202427
50 mg
$122.00
1
(1)

MTA-D is a synthetic derivative of MTA and has been studied for its potential as an MAT1 inhibitor.