LARP1 Activators
LARP1 Activators comprise a collection of chemical compounds that indirectly enhance the functional activity of LARP1, primarily through their interactions with the mTOR pathway and its downstream effectors. Rapamycin, a quintessential mTOR inhibitor, plays a pivotal role in this modulation by inhibiting mTORC1, leading to decreased phosphorylation of 4E-BP1, a regulator of mRNA translation. This inhibition potentially accentuates LARP1's involvement in mRNA stability and translation, a key aspect of its functional role. Similarly, Torin 1, PP242, AZD8055, WYE-354, and Ku-0063794, all of which are mTOR inhibitors, contribute to this modulation by targeting mTORC1 and mTORC2. The resultant decrease in phosphorylation of 4E-BP1 and S6K1 further emphasizes LARP1's regulatory capacity in mRNA translation. These compounds collectively underscore the intricate relationship between mTOR signaling and LARP1's functional role in mRNA metabolism.
Beyond the realm of strict mTOR inhibition, compounds like Palomid 529, BEZ235, PF-04691502, and OSI-027, which inhibit both PI3K and mTOR pathways, further enhance LARP1's activity. This broad-spectrum inhibition leads to an overall decrease in kinase activity within these pathways, potentially bolstering LARP1's role in mRNA stability and translation regulation. Everolimus and Temsirolimus, specifically targeting mTORC1, align with this theme of enhancing LARP1's functional activity by modulating the mTOR pathway. This collective action of LARP1 Activators, via their targeted influence on key signaling pathways, culminates in an augmented role for LARP1 in the regulation of mRNA translation and stability, crucial aspects of cellular function and homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, indirectly enhances LARP1 activity by inhibiting the mTOR pathway. This inhibition leads to reduced phosphorylation of 4E-BP1, a key regulator of mRNA translation, thereby potentially increasing LARP1's involvement in mRNA stabilization and translation. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
Torin 1, another mTOR inhibitor, enhances LARP1 function by inhibiting mTORC1 and mTORC2, leading to decreased phosphorylation of 4E-BP1 and S6K1. This enhances LARP1's role in mRNA stability and translation regulation. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
AZD8055, a potent mTOR inhibitor, enhances LARP1 function by inhibiting mTORC1 and mTORC2, leading to a decrease in phosphorylation of key translation regulators like 4E-BP1, thereby potentially augmenting LARP1's role in mRNA translation. | ||||||
WYE-354 | 1062169-56-5 | sc-364652 sc-364652A | 10 mg 50 mg | $286.00 $1200.00 | ||
WYE-354, targeting mTOR, indirectly enhances LARP1 activity by inhibiting mTOR kinase, leading to decreased phosphorylation of 4E-BP1, which may increase LARP1's involvement in the regulation of mRNA translation. | ||||||
KU 0063794 | 938440-64-3 | sc-361219 | 10 mg | $209.00 | ||
Ku-0063794, an mTOR inhibitor, enhances LARP1's role in mRNA translation by inhibiting mTORC1 and mTORC2, leading to reduced phosphorylation of key translation regulators such as 4E-BP1. | ||||||
Palomid 529 | 914913-88-5 | sc-364563 sc-364563A | 10 mg 50 mg | $300.00 $1000.00 | ||
Palomid 529, a PI3K/Akt/mTOR pathway inhibitor, indirectly enhances LARP1 activity by inhibiting downstream signaling, potentially increasing LARP1's role in mRNA stability and translation. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $211.00 | 8 | |
BEZ235, a dual PI3K/mTOR inhibitor, enhances LARP1 function by inhibiting both PI3K and mTOR pathways, potentially increasing LARP1's involvement in mRNA translation regulation. | ||||||
OSI-027 | 936890-98-1 | sc-364557 sc-364557A | 10 mg 50 mg | $437.00 $1186.00 | 1 | |
OSI-027, an mTOR inhibitor, enhances LARP1 function by inhibiting mTORC1 and mTORC2, potentially augmenting LARP1's role in mRNA translation regulation. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $131.00 $651.00 | 7 | |
Everolimus, an mTOR inhibitor, indirectly enhances LARP1 activity by inhibiting mTORC1, leading to a decrease in phosphorylation of 4E-BP1 and thus potentially increasing LARP1's involvement in mRNA stability and translation. | ||||||