INTS9 Activators
INTS9, known as Integrator Complex Subunit 9, is a component of the Integrator complex, which is a multi-protein entity closely associated with RNA polymerase II (Pol II). This complex is involved in the 3'-end processing of small nuclear RNAs (snRNAs), which are crucial for the splicing of pre-messenger RNA (mRNA).The Integrator complex consists of several subunits, each contributing to its functionalities, including the biogenesis of snRNAs. These snRNAs are integral to the spliceosome, the molecular machine responsible for editing pre-mRNA by excising introns and ligating exons to form mature messenger RNA, ready for translation into proteins. The unique role of the Integrator complex in snRNA processing distinguishes it from other RNA processing mechanisms, such as the cleavage and polyadenylation of mRNA precursors.
While the precise function of INTS9 within the complex is not fully elucidated, it is assumed to have a role in the structural cohesion and operational efficiency of the Integrator complex. By influencing the complex's stability and interaction with Pol II, INTS9 indirectly impacts the processing of snRNAs and the regulation of gene expression.Disruptions in INTS9 or other subunits of the Integrator complex may have significant biological consequences, potentially leading to a range of genetic disorders or contributing to the pathogenesis of certain cancers. This is due to the complex's involvement in the critical processes of RNA processing and gene expression regulation, which are fundamental to cell function and homeostasis.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA methyltransferase inhibitor can indirectly influence INTS9 by modifying gene expression patterns, potentially affecting the integrator complex. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Vorinostat, a histone deacetylase inhibitor, could indirectly impact INTS9 activity through changes in transcriptional regulation and chromatin remodeling. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
As a proteasome inhibitor, MG-132 might indirectly affect INTS9 by stabilizing proteins involved in RNA processing, thus influencing the integrator complex's function. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
By inhibiting nuclear export, Leptomycin B could indirectly influence INTS9 activity by altering the distribution and availability of RNA processing factors within the nucleus. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
This compound disrupts the Golgi apparatus and could indirectly affect INTS9 by altering cellular trafficking and signaling pathways intersecting with RNA processing. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1, a BET bromodomain inhibitor, may influence transcriptional regulation, indirectly impacting INTS9 activity through changes in the expression of genes related to the integrator complex. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, can alter various cellular pathways, including those related to RNA processing, potentially influencing INTS9 activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
This histone deacetylase inhibitor can alter chromatin structure and gene expression, potentially impacting INTS9 activity indirectly through transcriptional regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor, LY294002, could indirectly influence INTS9 by modulating PI3K/Akt signaling pathways that intersect with RNA processing and integrator complex function. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
By inhibiting protein synthesis, Cycloheximide could indirectly affect INTS9 activity through global changes in the proteome that influence RNA processing. | ||||||