GPATCH3 Activators
Targeting GPATCH3's upstream transcriptional pathways provides a precision approach. Resveratrol and ATRA activate factors interacting directly with promoter response elements like RAREs and SREs to potentiate basal GPATCH3 expression. Small molecules also address repressive mechanisms by inhibiting DNA methylation with NF-kB signaling with sulfasalazine and Bay 11609. Everolimus and scriptaid conversely liberate activator binding through mTOR inhibition and histone deacetylation prevention.
Further activation strategies involve directly stimulating critical promoter-bound proteins. For example, WP1066 increases GATA3 association while AP-DC and bisbenzimide enhance AP-1 and SP1 engagement with their cognate sites. These agents present both direct and indirect options centered on core promoter components and proximal signaling events governing GPATCH3 levels. Determining individual and combination effects on transcriptional regulation continues interrogating modulation of this gene.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which deacetylates transcription factors that bind the GPATCH3 promoter to enhance gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Tretinoin activates RAR nuclear receptors that heterodimerize with RXR on RARE elements in the GPATCH3 promoter to increase transcription. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $131.00 $651.00 | 7 | |
The mTOR inhibitor everolimus liberates FOXO factors for FOXO response element binding in the GPATCH3 promoter. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $64.00 $183.00 | 11 | |
The HDAC inhibitor scriptaid prevents repressive histone deacetylation near regulatory regions of the GPATCH3 gene. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Sulfasalazine inhibits NF-kB to prevent binding at kappaB sites that negatively regulate GPATCH3 transcription. | ||||||
Stat3 Inhibitor III, WP1066 | 857064-38-1 | sc-203282 | 10 mg | $132.00 | 72 | |
WP1066 activates GATA3 enhancing its association with promoter sites that drive GPATCH3 expression. | ||||||