Date published: 2026-4-23

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GluR-2 Activators

GluR-2 activators are a class of chemical compounds that interact specifically with the GluR-2 (Glutamate Receptor 2) subtype of ionotropic glutamate receptors. These receptors, primarily found in the central nervous system, play a crucial role in mediating fast excitatory synaptic transmission. GluR-2 activators modulate the activity of these receptors by binding to their binding sites, leading to distinct physiological effects within the nervous system.At the molecular level, GluR-2 activators exert their influence by selectively enhancing the function of GluR-2-containing AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. AMPA receptors are responsible for mediating the majority of fast excitatory synaptic transmission in the brain. GluR-2 activators promote the stabilization of GluR-2 subunits within these receptors, which is significant because GluR-2 subunits are known to confer calcium impermeability to AMPA receptors. This selective property is vital for preventing excessive calcium influx, which can lead to neuronal excitotoxicity. By enhancing GluR-2-containing AMPA receptors' function, these activators play a role in maintaining the delicate balance of excitatory neurotransmission, ultimately contributing to the overall homeostasis of neuronal signaling within the central nervous system. Understanding the precise mechanisms by which GluR-2 activators interact with GluR-2 receptors provides valuable insights into the fundamental processes
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Cl-HIBO

909400-43-7sc-205934
sc-205934A
10 mg
50 mg
$229.00
$970.00
(0)

Cl-HIBO (CAS 909400-43-7) is a chemical compound that activates GluR-2-containing AMPA receptors, modulating excitatory synaptic transmission.

(S)-CPW 399

389888-02-2sc-203690
sc-203690A
10 mg
50 mg
$300.00
$865.00
(0)

(S)-CPW 399 (CAS 389888-02-2) is a chemical compound known for its role as a GluR-2 activator, contributing to the modulation of excitatory neurotransmission.

Aniracetam

72432-10-1sc-203514
sc-203514A
50 mg
250 mg
$115.00
$456.00
(1)

Aniracetam is a nootropic compound that enhances GluR-2-containing AMPA receptor function by positively modulating receptor activity. It appears to increase receptor conductance, leading to improved synaptic transmission and cognitive effects.

Cyclothiazide

2259-96-3sc-202560
sc-202560A
10 mg
50 mg
$107.00
$227.00
3
(1)

Cyclothiazide is a positive allosteric modulator of GluR-2-containing AMPA receptors. It binds to specific sites on the receptor and slows receptor desensitization, resulting in increased receptor activity and prolonged excitatory synaptic transmission.

PEPA

141286-78-4sc-204178
sc-204178A
10 mg
50 mg
$131.00
$582.00
(0)

PEPA, or 4-Phenyl-2,3,4,5-tetrahydro-1H-pyrazolo[3,4-c]pyridin-6-yl, is a synthetic compound known to enhance GluR-2-containing AMPA receptor currents, likely by binding to receptor sites and increasing their activity.

Farampator

211735-76-1sc-497755
10 mg
$300.00
1
(0)

Farampator is a selective GluR-2 activator, though the precise mechanism of its action is not fully elucidated. It is believed to enhance GluR-2-containing AMPA receptor currents, potentially influencing synaptic plasticity.

GYKI 53655 hydrochloride

143692-48-2sc-361203
sc-361203A
10 mg
50 mg
$228.00
$966.00
(0)

GYKI 53655 hydrochloride antagonizes AMPA receptor desensitization, effectively increasing GluR-2 receptor activity. This action helps maintain prolonged synaptic transmission by preventing rapid receptor inactivation.

ZK 200775

161605-73-8sc-204421
sc-204421A
10 mg
50 mg
$189.00
$796.00
(0)

ZK 200775 is a selective GluR-2 modulator believed to influence the functioning of GluR-2-containing AMPA receptors. Its specific mode of activation and its potential impact on synaptic transmission are subjects of research.