Eps8 Activators
Eps8 Activators encompass a collection of chemical compounds that enhance the functional activity of Eps8 through various signaling pathways and interactions with the actin cytoskeleton. Phalloidin and Jasplakinolide amplify Eps8's capping and bundling functions by stabilizing actin filaments, ensuring a robust architecture for cellular processes dependent on cytoskeletal dynamics. Blebbistatin and Cytochalasin D, by modulating actin-myosin interactions and inhibiting actin polymerization respectively, create conditions that favor the actin capping activity of Eps8, thus facilitating its role in actin filament maintenance and rearrangement. Latrunculin A, through its preferential binding to actin monomers, increases the pool of available G-actin, indirectly promoting the capping efficiency of Eps8, while Calyculin A, by inhibiting protein phosphatases, might lead to a phosphorylation state that favors Eps8's interaction with actin. ML141 and NSC23766, as inhibitors of the small GTPases CDC42 and Rac1, could potentially skew cellular signaling pathways towards those that enhance Eps8-mediated actin remodeling, integral to cellular protrusion formation and motility.
In addition, PDGF-BB, by activating growth factor signaling pathways, and Forskolin, by increasing intracellular cAMP levels, indirectly foster an environment conducive to Eps8's functional activity in actin reorganization. Manumycin A, through its inhibition of Ras farnesyltransferase, may also potentiate Eps8's role in signaling pathways that influence actin cytoskeletal rearrangements. The collective action of these compounds serves to potentiate the cellular functions of Eps8, specifically in the context of actin filament dynamics, without necessitating the upregulation of its expression or direct activation. This precise modulation of Eps8's activity by diverse chemical activators underscores the intricate regulatory mechanisms that govern cellular cytoskeletal dynamics and the potential for targeted intervention in pathways involving Eps8.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Stabilizes actin filaments and prevents their disassembly, enhancing Eps8's role in actin filament capping. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Stabilizes actin filaments, potentially increasing Eps8-mediated capping and bundling of actin structures. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
ROCK inhibitor that promotes actin cytoskeleton remodelling, potentially augmenting Eps8's actin-related roles. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Inhibits myosin II, thus could enhance Eps8 activity in cells by affecting actin-myosin interactions. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Binds to actin monomers and prevents polymerization, possibly enhancing the capping ability of Eps8. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Inhibits actin polymerization and enhances Eps8's capping and bundling activity by increasing actin turnover. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
CDC42 inhibitor, potentially enhancing Eps8-mediated changes in the actin cytoskeleton. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
Inhibitor of Rac1, may synergize with Eps8's role in actin remodeling and cellular protrusions. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylyl cyclase increasing cAMP, which can indirectly enhance Eps8-mediated actin remodeling. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Inhibits protein phosphatases 1 and 2A, possibly resulting in enhanced Eps8 activity in actin dynamics. | ||||||