Date published: 2026-6-6

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EID-2 Inhibitors

EID-2 inhibitors are chemical compounds that influence the activity of EID-2, a protein that modulates gene expression through interaction with histone deacetylases (HDACs). These inhibitors predominantly target HDACs, which are enzymes that EID-2 recruits to repress transcription by removing acetyl groups from histones, leading to a more condensed chromatin structure and reduced gene expression. By inhibiting HDACs, these compounds effectively increase histone acetylation, thereby preventing EID-2 from exerting its repressive effects on gene transcription. Compounds such as Trichostatin A, Vorinostat, and Romidepsin are known to be potent HDAC inhibitors that can disrupt the normal function of EID-2 by altering the acetylation status of histones, which is a critical factor in the regulation of gene expression by EID-2. Furthermore, EID-2's inhibitory function on gene expression is closely tied to its ability to interact with HDACs. By inhibiting these enzymes, compounds like Sodium Butyrate, MS-275, and SAHA can interfere with the repressive chromatin remodeling usually facilitated by EID-2. Selective inhibitors such as Entinostat and Mocetinostat are designed to target specific HDAC classes, which could provide a more focused approach in disrupting EID-2 activity. Broad-spectrum inhibitors like Panobinostat and Belinostat may affect multiple HDAC enzymes, potentially exerting a wider range of influence on EID-2's role in transcriptional repression. Chidamide, as an HDAC inhibitor, can also impact chromatin remodeling and gene expression, which may interfere with the EID-2-associated repression of transcription.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$152.00
$479.00
$632.00
$1223.00
$2132.00
33
(3)

Histone deacetylase inhibitor that increases acetylation of histones, leading to changes in gene expression. EID-2 is known to interact with histone deacetylases; inhibition of these enzymes can prevent EID-2 from exerting its repressive effects on gene transcription.

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$133.00
$275.00
37
(2)

Histone deacetylase inhibitor that similarly to Trichostatin A, increases histone acetylation and can disrupt EID-2's interaction with HDACs, reducing its transcriptional repression capability.

Romidepsin

128517-07-7sc-364603
sc-364603A
1 mg
5 mg
$218.00
$634.00
1
(1)

Another histone deacetylase inhibitor that can alter chromatin structure and gene expression, potentially impeding EID-2's ability to modify gene transcription through its effects on histone modification.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$31.00
$47.00
$84.00
$222.00
19
(3)

Histone deacetylase inhibitor that increases histone acetylation in cells, which could counteract EID-2's repression of gene transcription by altering the acetylation status of histones.

MS-275

209783-80-2sc-279455
sc-279455A
sc-279455B
1 mg
5 mg
25 mg
$24.00
$90.00
$212.00
24
(2)

Selective histone deacetylase inhibitor that targets HDAC class I, potentially disrupting the function of EID-2 which is linked to HDAC activity.

Valproic Acid

99-66-1sc-213144
10 g
$87.00
9
(1)

HDAC inhibitor that can alter gene expression and potentially interfere with EID-2's ability to repress transcription through its effects on histone modification.

Mocetinostat

726169-73-9sc-364539
sc-364539B
sc-364539A
5 mg
10 mg
50 mg
$214.00
$247.00
$1463.00
2
(1)

HDAC inhibitor that could disrupt the interaction between EID-2 and HDACs, therefore modulating the transcriptional repression usually mediated by EID-2.

Panobinostat

404950-80-7sc-208148
10 mg
$200.00
9
(1)

Broad-spectrum HDAC inhibitor that can disrupt multiple HDAC enzymes, potentially affecting EID-2's role in transcriptional repression.

Belinostat

414864-00-9sc-269851
sc-269851A
10 mg
100 mg
$156.00
$572.00
(1)

Pan-HDAC inhibitor that may indirectly inhibit EID-2 activity by increasing histone acetylation and disrupting HDAC-mediated transcriptional repression.

Chidamide

743420-02-2sc-364462
sc-364462A
sc-364462B
1 mg
5 mg
25 mg
$62.00
$250.00
$1196.00
(1)

HDAC inhibitor that can impact chromatin remodeling and gene expression, which may interfere with the EID-2-associated repression of transcription.