DAT Activators
Common DAT Activators include, but are not limited to Forskolin CAS 66575-29-9, Valproic acid sodium salt CAS 1069-66-5, Dexamethasone CAS 50-02-2, PMA CAS 16561-29-8 and Trichostatin A CAS 58880-19-6.
The chemical class of DAT Activators are compounds that interact with and modulate the activity of the dopamine transporter (DAT). The dopamine transporter is a membrane protein found in neurons that plays a crucial role in regulating the levels of dopamine in the synaptic cleft. This process is essential for maintaining proper neurotransmission and communication between neurons in the brain. DAT is responsible for reuptake of dopamine from the synaptic cleft back into the presynaptic neuron, thereby terminating the signaling of dopamine and allowing for precise control over neurotransmitter concentrations.
The modulation of DAT activity by DAT Activators can have significant implications for understanding the regulation of dopamine signaling and neurotransmission in the brain. By influencing the activity of DAT, researchers can explore the intricate balance between dopamine release, reuptake, and clearance, which is critical for normal brain function and is associated with various neuropsychiatric disorders, including attention deficit hyperactivity disorder (ADHD), Parkinson's disease, and substance use disorders. Studying DAT Activators can provide insights into the complex interplay between neurotransmitters, transporters, and receptors in the brain, shedding light on how disruptions in dopamine homeostasis may contribute to neurological and psychiatric conditions. This line of research is aimed at advancing our understanding of the underlying molecular mechanisms and biological strategies related to DAT function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular levels of cyclic AMP (cAMP), which activates the transcription factor CREB. Activated CREB can bind to the DAT gene promoter, leading to increased transcription and subsequent DAT expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid is a histone deacetylase (HDAC) inhibitor. By inhibiting HDACs, it promotes histone acetylation, potentially facilitating an open chromatin structure around the DAT gene promoter. This can enhance gene transcription and DAT expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoids like dexamethasone can interact with glucocorticoid response elements within the DAT gene promoter region. This interaction can lead to the upregulation of DAT expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can trigger signaling pathways that affect DAT expression regulation. | ||||||
Rotigotine Hydrochloride | 125572-93-2 | sc-212790 | 25 mg | $290.00 | ||
Dopamine agonists suech as Rotigotine Hydrochloride can activate dopamine receptors, leading to downstream signaling events that may influence DAT expression as part of complex feedback mechanisms. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA is an HDAC inhibitor that increases histone acetylation, potentially leading to enhanced transcription of the DAT gene and increased DAT expression. | ||||||