Molecular structure of Rotigotine Hydrochloride, CAS Number: 125572-93-2
Rotigotine Hydrochloride (CAS 125572-93-2)
Application:
Rotigotine Hydrochloride is a D2DR and D3DR agonist
CAS Number:
125572-93-2
Purity:
≥99%
Molecular Weight:
351.93
Molecular Formula:
C19H25NOS•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A non-ergot dopamine agonist drug which is indicated for the treatment of Parkinson′s disease.
Rotigotine Hydrochloride (CAS 125572-93-2) References
- Plasma levels of rotigotine and the reversal of motor deficits in MPTP-treated primates. | Rose, S., et al. 2007. Behav Pharmacol. 18: 155-60. PMID: 17351422
- Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction. | Stockwell, KA., et al. 2009. Exp Neurol. 219: 533-42. PMID: 19619533
- Continuous rotigotine administration reduces dyskinesia resulting from pulsatile treatment with rotigotine or L-DOPA in MPTP-treated common marmosets. | Stockwell, KA., et al. 2010. Exp Neurol. 221: 79-85. PMID: 19833125
- Rotigotine polyoxazoline conjugate SER-214 provides robust and sustained antiparkinsonian benefit. | Eskow Jaunarajs, KL., et al. 2013. Mov Disord. 28: 1675-82. PMID: 24014074
- Rotigotine: the first new chemical entity for transdermal drug delivery. | McAfee, DA., et al. 2014. Eur J Pharm Biopharm. 88: 586-93. PMID: 25173087
- New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling. | Brust, TF., et al. 2015. Biochem Pharmacol. 93: 85-91. PMID: 25449598
- A potential tailor-made hyaluronic acid buccal delivery system comprising rotigotine for Parkinson's disease? | Laffleur, F., et al. 2015. Future Med Chem. 7: 1225-32. PMID: 26144261
- In vivo dopamine agonist properties of rotigotine: Role of D1 and D2 receptors. | Fenu, S., et al. 2016. Eur J Pharmacol. 788: 183-191. PMID: 27343381
- Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. | Chen, Y., et al. 2016. Sci Signal. 9: ra74. PMID: 27460988
- Rotigotine, a dopamine receptor agonist, increased BDNF protein levels in the rat cortex and hippocampus. | Adachi, N., et al. 2018. Neurosci Lett. 662: 44-50. PMID: 28993209
- Dopamine D2/D3 receptor agonists attenuate PTSD-like symptoms in mice exposed to single prolonged stress. | Malikowska-Racia, N., et al. 2019. Neuropharmacology. 155: 1-9. PMID: 31085186
- Heteromerization between α2A adrenoceptors and different polymorphic variants of the dopamine D4 receptor determines pharmacological and functional differences. Implications for impulsive-control disorders. | Casadó-Anguera, V., et al. 2021. Pharmacol Res. 170: 105745. PMID: 34182128
- Characterization of the discriminative stimulus effect of quinpirole: Further evidence for functional interaction between central dopamine D1/D2-receptors. | Mori, T., et al. 2022. Pharmacol Biochem Behav. 213: 173314. PMID: 34919902
- Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts. | Gomes, I., et al. 2022. Foods. 11: PMID: 35267379
Activator of:
D2DR, D3DR, DAT, and RXRβ2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rotigotine Hydrochloride, 25 mg | sc-212790 | 25 mg | $290.00 |