TMPRSS11D Activators
TMPRSS11D Activators belong to a distinctive chemical class characterized by their ability to modulate the activity of the Transmembrane Protease, Serine 11D (TMPRSS11D). TMPRSS11D is a member of the serine protease family, enzymes known for their involvement in crucial physiological processes, such as blood clotting, digestion, and immune response. Specifically, TMPRSS11D is situated on the cell membrane and plays a pivotal role in the activation of certain proteins through proteolytic cleavage. The activators associated with TMPRSS11D exhibit a unique molecular signature that allows them to interact with the enzyme, influencing its catalytic activity.
Structurally, TMPRSS11D Activators possess specific functional groups and binding motifs that enable them to selectively engage with the active site of TMPRSS11D, promoting or modulating its enzymatic function. These activators are designed to interact with the enzyme in a manner that influences substrate recognition and processing. The modulation of TMPRSS11D activity is crucial in various biological contexts, including cellular signaling, tissue development, and host-pathogen interactions. Understanding the intricate details of TMPRSS11D Activators at the molecular level provides insights into the regulatory mechanisms governing cellular processes in which TMPRSS11D is involved. Research in this chemical class sheds light on the intricate interplay between serine proteases and their activators, contributing to the broader understanding of molecular biology and avenues for targeted interventions in relevant biological pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nobiletin | 478-01-3 | sc-202733 | 10 mg | $189.00 | 2 | |
Nobiletin, a polymethoxylated flavone, enhances TMPRSS11D by activating the PI3K/AKT pathway. It binds to the PI3K p85 subunit, promoting its membrane localization and subsequently activating AKT, which positively regulates TMPRSS11D by phosphorylation-mediated enhancement. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $56.00 $180.00 | 8 | |
Ursolic Acid enhances TMPRSS11D by influencing the NF-κB pathway. It inhibits IκBα degradation, leading to NF-κB nuclear translocation and transcriptional activation of TMPRSS11D. This direct involvement in the NF-κB signaling pathway enhances TMPRSS11D expression and activity. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin enhances TMPRSS11D through the MAPK/ERK pathway. It activates MEK1/2, which subsequently phosphorylates and activates ERK. Activated ERK translocates to the nucleus, where it modulates transcription factors that positively regulate TMPRSS11D expression, contributing to enhanced functional activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol enhances TMPRSS11D by activating the SIRT1/AMPK pathway. It activates SIRT1, leading to AMPK activation. Activated AMPK positively regulates TMPRSS11D through direct phosphorylation events, enhancing its functional activity in cellular processes. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein enhances TMPRSS11D by influencing the JAK/STAT pathway. It inhibits JAK phosphorylation, preventing STAT negative regulation. This results in increased STAT activation, leading to enhanced TMPRSS11D expression and functional activity through direct transcriptional regulation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin enhances TMPRSS11D through the Wnt/β-catenin pathway. It inhibits GSK-3β, leading to β-catenin stabilization and nuclear translocation. In the nucleus, β-catenin positively regulates TMPRSS11D transcription, thereby enhancing its functional activity in cellular processes. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol enhances TMPRSS11D by modulating the Hedgehog signaling pathway. It promotes GLI1 transcriptional activity by inhibiting its negative regulator, Sufu. Enhanced GLI1 activity positively regulates TMPRSS11D expression, contributing to increased functional activity. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic Acid enhances TMPRSS11D by influencing the mTOR pathway. It inhibits mTORC1, leading to 4E-BP1 and S6K activation. Activated 4E-BP1 and S6K positively regulate TMPRSS11D expression, contributing to enhanced functional activity in cellular processes. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin enhances TMPRSS11D by activating the Nrf2/ARE pathway. It induces Nrf2 nuclear translocation, promoting ARE-driven gene expression. Nrf2 positively regulates TMPRSS11D expression, leading to increased functional activity in cellular processes through direct transcriptional control. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid enhances TMPRSS11D by influencing the TLR4/NF-κB pathway. It inhibits TLR4 activation, preventing NF-κB negative regulation. This results in increased NF-κB activation, leading to enhanced TMPRSS11D expression and functional activity through direct transcriptional regulation. | ||||||