TMPRSS11D Antibody (C-9): sc-515673
- TMPRSS11D Antibody (C-9) is a mouse monoclonal IgG2a κ TMPRSS11D antibody provided at 200 µg/ml
- raised against amino acids 39-194 mapping near the N-terminus of TMPRSS11D of human origin
- TMPRSS11D Antibody (C-9) is recommended for detection of TMPRSS11D of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-TMPRSS11D Antibody (C-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TMPRSS11D Antibody (C-9) for WB applications. These reagents are now offered in bundles with TMPRSS11D Antibody (C-9) (see ordering information below).
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TMPRSS11D Antibody (C-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects TMPRSS11D of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-TMPRSS11D antibody (C-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TMPRSS11D, also known as transmembrane protease, serine 11D or HAT, is a 418 amino acid single-pass type II membrane protein characterized by one SEA domain and one peptidase S1 domain. TMPRSS11D is primarily expressed in bronchi and trachea, where TMPRSS11D plays a crucial role in host defense by cleaving C-terminal side of arginine residues at P1 position of specific peptides. This enzymatic activity modulates various physiological processes, including activation of other proteins involved in immune responses. TMPRSS11D undergoes post-translational modifications, including cleavage that forms an active, secreted peptide, enhancing functional versatility. The TMPRSS11D gene is located on human chromosome 4, a region known for extensive gene deserts comprising nearly 6% of the human genome, highlighting evolutionary significance and potential implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TMPRSS11D Antibody (C-9) References:
- Localization of human airway trypsin-like protease in the airway: an immunohistochemical study. | Takahashi, M., et al. 2001. Histochem Cell Biol. 115: 181-7. PMID: 11326745
- Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cells. | Miki, M., et al. 2003. J Med Invest. 50: 95-107. PMID: 12630574
- Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris. | Iwakiri, K., et al. 2004. J Invest Dermatol. 122: 937-44. PMID: 15102084
- Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway. | Matsushima, R., et al. 2006. Am J Physiol Lung Cell Mol Physiol. 290: L385-95. PMID: 16199437
- Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells. | Chokki, M., et al. 2005. FEBS J. 272: 6387-99. PMID: 16336275
- Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium. | Böttcher, E., et al. 2006. J Virol. 80: 9896-8. PMID: 16973594
- Purification, characterization, and localization of a novel trypsin-like protease found in the human airway. | Yasuoka, S., et al. 1997. Am J Respir Cell Mol Biol. 16: 300-8. PMID: 9070615
- Cloning and characterization of the cDNA for human airway trypsin-like protease. | Yamaoka, K., et al. 1998. J Biol Chem. 273: 11895-901. PMID: 9565616
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TMPRSS11D Antibody (C-9) | sc-515673 | 200 µg/ml | $316.00 | |||
TMPRSS11D Antibody (C-9): m-IgG Fc BP-HRP Bundle | sc-531463 | 200 µg Ab; 10 µg BP | $354.00 | |||
TMPRSS11D Antibody (C-9): m-IgGκ BP-HRP Bundle | sc-525158 | 200 µg Ab, 40 µg BP | $354.00 | |||
TMPRSS11D Antibody (C-9): m-IgG2a BP-HRP Bundle | sc-547795 | 200 µg Ab; 10 µg BP | $354.00 | |||
TMPRSS11D Antibody (C-9) AC | sc-515673 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TMPRSS11D Antibody (C-9) HRP | sc-515673 HRP | 200 µg/ml | $316.00 | |||
TMPRSS11D Antibody (C-9) FITC | sc-515673 FITC | 200 µg/ml | $330.00 | |||
TMPRSS11D Antibody (C-9) PE | sc-515673 PE | 200 µg/ml | $343.00 | |||
TMPRSS11D Antibody (C-9) Alexa Fluor® 488 | sc-515673 AF488 | 200 µg/ml | $357.00 | |||
TMPRSS11D Antibody (C-9) Alexa Fluor® 546 | sc-515673 AF546 | 200 µg/ml | $357.00 | |||
TMPRSS11D Antibody (C-9) Alexa Fluor® 594 | sc-515673 AF594 | 200 µg/ml | $357.00 | |||
TMPRSS11D Antibody (C-9) Alexa Fluor® 647 | sc-515673 AF647 | 200 µg/ml | $357.00 | |||
TMPRSS11D Antibody (C-9) Alexa Fluor® 680 | sc-515673 AF680 | 200 µg/ml | $357.00 | |||
TMPRSS11D Antibody (C-9) Alexa Fluor® 790 | sc-515673 AF790 | 200 µg/ml | $357.00 |