Inhibiteurs SLC17A2
SLC17A2 inhibitors are a class of chemical compounds that specifically target and inhibit the function of the SLC17A2 protein, a member of the solute carrier family. SLC17A2 is part of the larger SLC17 family, which is known for its role in transporting organic anions, including neurotransmitters and other small molecules, across cellular membranes. The inhibition of SLC17A2 can disrupt the transport processes it mediates, offering researchers a powerful tool to study the protein's function and its broader impact on cellular activities. By selectively inhibiting SLC17A2, scientists can explore how this transporter influences the distribution and concentration of specific anions within cells, and how these changes affect cellular metabolism and signaling.
The use of SLC17A2 inhibitors in research is particularly valuable for dissecting the role of this transporter in various biological systems. By blocking SLC17A2 activity, researchers can observe the resulting alterations in cellular processes, such as changes in ion gradients, neurotransmitter release, and intracellular signaling pathways. These studies help to elucidate the specific substrates transported by SLC17A2 and the physiological contexts in which this transporter is most active. Additionally, SLC17A2 inhibitors can be used to explore the regulatory mechanisms that control the expression and activity of this protein, providing insights into how cells maintain homeostasis in response to environmental and intracellular cues. Through these investigations, SLC17A2 inhibitors contribute to a deeper understanding of membrane transport mechanisms and the complex interplay between transport proteins and cellular function.
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| Nom du produit | CAS # | Ref. Catalogue | Quantité | Prix HT | CITATIONS | Classement |
|---|---|---|---|---|---|---|
D(−)-2-Amino-5-phosphonovaleric acid (D-AP5) | 79055-68-8 | sc-200434 | 5 mg | $95.00 | 2 | |
En tant qu'antagoniste des récepteurs NMDA, l'AP5 peut influencer indirectement la signalisation et la libération de glutamate. | ||||||
6-Cyano-7-nitroquinoxaline-2,3-dione | 115066-14-3 | sc-505104 | 10 mg | $204.00 | 2 | |
Le CNQX est un puissant antagoniste des récepteurs AMPA, qui influence indirectement la signalisation et la libération du glutamate. | ||||||
Kynurenic acid | 492-27-3 | sc-202683 sc-202683A sc-202683B | 250 mg 1 g 5 g | $25.00 $56.00 $135.00 | 6 | |
Il s'agit d'un antagoniste à large spectre des récepteurs des acides aminés excitateurs, réduisant ainsi la signalisation du glutamate. | ||||||
Riluzole | 1744-22-5 | sc-201081 sc-201081A sc-201081B sc-201081C | 20 mg 100 mg 1 g 25 g | $20.00 $189.00 $209.00 $311.00 | 1 | |
Le riluzole inhibe la libération de glutamate, influençant indirectement la fonction de SLC17A7. | ||||||
Ethosuximide | 77-67-8 | sc-211431 | 1 g | $300.00 | ||
Ce composé réduit l'activité des canaux calciques de type T, ce qui peut influencer indirectement la libération de glutamate. | ||||||
Lamotrigine | 84057-84-1 | sc-201079 sc-201079A | 10 mg 50 mg | $118.00 $476.00 | 1 | |
La lamotrigine inhibe les canaux sodiques sensibles à la tension, ce qui entraîne une diminution de la libération de glutamate. | ||||||
Topiramate | 97240-79-4 | sc-204350 sc-204350A | 10 mg 50 mg | $105.00 $362.00 | ||
Elle module les courants évoqués par le GABA, influençant indirectement la libération de glutamate. | ||||||
Felbamate | 25451-15-4 | sc-203579 sc-203579A | 10 mg 50 mg | $101.00 $373.00 | ||
Le felbamate agit comme un antagoniste des récepteurs NMDA, affectant indirectement la signalisation et la libération de glutamate. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $92.00 $348.00 | 46 | |
Un protonophore, qui perturbe les gradients de protons, influençant potentiellement la fonction du SLC17A. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $31.00 | 3 | |
Anti-inflammatoire non stéroïdien, peut affecter indirectement les canaux ioniques et les transporteurs comme le SLC17A. | ||||||