DSN1 Activateurs
DSN1," or "Dosage Suppression of NNF1," is a gene that encodes a protein component of the kinetochore complex. The kinetochore is a vital structure composed of proteins assembled on the centromere, which is the part of a chromosome that links sister chromatids. During cell division, specifically mitosis and meiosis, kinetochores are responsible for the attachment of chromosomes to the spindle microtubules, enabling their accurate segregation into daughter cells.The DSN1 protein is a part of the MIS12 complex within the kinetochore, which is essential for the proper assembly and function of the kinetochore. It serves as a crucial connection point between the inner kinetochore proteins, which bind directly to the centromeric DNA, and the outer kinetochore proteins, which interact with the spindle microtubules.
DSN1's role is not merely structural; it is also implicated in the signaling pathways that ensure the correct attachment of the kinetochore to the spindle fibers. This includes the spindle assembly checkpoint, a critical surveillance mechanism that prevents the onset of anaphase until all chromosomes are properly attached to the spindle, thus ensuring accurate chromosome segregation and genomic stability.Mutations or dysregulation of the DSN1 gene or protein can lead to chromosomal missegregation, aneuploidy, and contribute to the development of various cancers.
VOIR ÉGALEMENT...
| Nom du produit | CAS # | Ref. Catalogue | Quantité | Prix HT | CITATIONS | Classement |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Le paclitaxel stabilise les microtubules et peut indirectement affecter DSN1 en modifiant les interactions entre le kinétochore et les microtubules pendant la division cellulaire. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Le nocodazole, un agent de dépolymérisation des microtubules, peut influencer l'assemblage du fuseau et avoir un impact indirect sur la fonction de DSN1 dans le kinétochore. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Inhibiteur de la kinésine Eg5, Monastrol perturbe la formation du fuseau, affectant potentiellement le rôle de DSN1 dans le kinétochore. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
La colchicine se lie à la tubuline et inhibe la polymérisation des microtubules, affectant indirectement la fonction de DSN1 dans la ségrégation des chromosomes. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
La vinblastine, un agent déstabilisant les microtubules, peut influencer la fonction des kinétochores et avoir un impact indirect sur DSN1. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $31.00 $65.00 | 6 | |
Inhibiteur spécifique d'Eg5, ce composé perturbe la dynamique du fuseau mitotique, ce qui pourrait avoir un impact sur la fonction de DSN1. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
Un inhibiteur de la kinase Aurora, le ZM447439, peut altérer la fonction du kinétochore, affectant indirectement DSN1. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
BI 2536, un inhibiteur de PLK1, peut perturber l'assemblage du fuseau et influencer indirectement DSN1 dans le kinétochore. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Inhibiteur de la kinase Aurora A, l'Alisertib peut affecter l'assemblage du fuseau et la fonction du kinétochore, ce qui a un impact indirect sur DSN1. | ||||||