SPT3 Activators
SPT3 activators are compounds that affect transcription initiation and chromatin modification indirectly. These chemicals interact with cellular components to create an intracellular environment that is conducive to the activation of transcription initiation protein SPT3 homolog by modifying the expression or function of genes and proteins associated with transcription. They range from histone deacetylase inhibitors, which relax chromatin structure, to secondary messengers that activate kinases, which in turn modulate transcription factor activity. Some compounds in this class also affect methylation patterns, influencing the transcriptional landscape to favor SPT3 activity.
These activators share the common characteristic of modulating epigenetic states or signal transduction pathways to create a cellular context that favors transcription initiation. They indirectly facilitate the recruitment or stabilization of the transcription machinery, including the SPT3 protein, at promoter regions of genes, enhancing the transcriptional initiation process.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP is a secondary messenger that activates protein kinase A (PKA). PKA can phosphorylate transcription factors and other proteins involved in the regulation of gene expression, which could enhance the transcriptional activity of SPT3 by promoting the assembly of the transcription initiation complex. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is known to have various effects on cell signaling and gene expression. It has been shown to affect DNA methylation and histone modification patterns, which could, in turn, affect transcription initiation and potentially increase SPT3 activity. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAMe serves as a methyl donor in numerous methylation reactions, including histone methylation. Altered histone methylation status can impact gene expression profiles and may enhance SPT3's role in transcription initiation. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
β-Estradiol binds to estrogen receptors which can interact with coactivator complexes and influence transcription. Its role in chromatin remodeling could lead to an environment that supports SPT3-mediated transcription initiation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid interacts with its receptors, which can modulate gene expression by remodeling chromatin. This can influence the recruitment and activity of the SPT3-containing SAGA complex during transcription initiation. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
BIX-01294 is an inhibitor of G9a histone methyltransferase, which methylates H3K9. Inhibition of G9a can lead to an open chromatin state, potentially facilitating the recruitment of the SPT3-containing SAGA complex to target gene promoters. | ||||||