DUSP (Dual specificity protein phosphatase) Inhibitors
Dual specificity phosphatases (DUSPs) are a group of enzymes that regulate cellular processes by dephosphorylating both tyrosine and serine/threonine residues on their substrate proteins. DUSPs play a critical role in controlling the activity of mitogen-activated protein kinases (MAPKs), which are key signaling molecules involved in cell proliferation, differentiation, and stress responses. By modulating MAPK activity, DUSPs can influence various cellular responses to extracellular signals. Their activity serves as a balancing mechanism in cellular signaling, ensuring that the activation of MAPK pathways is tightly regulated.
Research efforts in targeting Dual specificity phosphatases (DUSPs) for disruption or inhibition have gained interest, especially in the context of where MAPK signaling is aberrant. The development of these inhibitors is challenging due to the need for specificity and the complex nature of DUSP interactions within cellular signaling networks. Several compounds have been identified that show inhibitory activity against specific DUSPs, offering promising leads for development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NSC 95397 | 93718-83-3 | sc-203654 sc-203654A | 10 mg 50 mg | $255.00 $847.00 | 9 | |
NSC-95397 acts as an inhibitor of DUSPs by binding to its active site. By doing so, it disrupts the enzyme's ability to dephosphorylate its substrate proteins, including critical signaling molecules like ERK and JNK. This interference results in prolonged phosphorylation and activation of downstream signaling pathways. | ||||||
SBI-0206965 | 1884220-36-3 | sc-507431 | 10 mg | $124.00 | ||
SBI-0206965 is a small molecule DUSP inhibitor that disrupts DUSP's catalytic activity. It prevents the dephosphorylation of target proteins, leading to the sustained activation of signaling pathways affected by DUSP. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits DUSPs by disrupting its dephosphorylation activity towards JNK and other substrates. This results in the prolonged activation of JNK and downstream signaling events that impact cellular functions, including cell proliferation and apoptosis. | ||||||
ERK Inhibitor II, FR180204 | 865362-74-9 | sc-203945 sc-203945A sc-203945B sc-203945C | 1 mg 5 mg 10 mg 50 mg | $110.00 $165.00 $239.00 $942.00 | 45 | |
FR180204 is a chemical inhibitor of DUSPs. It operates by inhibiting the dephosphorylation activity of DUSPs, thereby enhancing the phosphorylation and activation of MAP kinases. This modulation of MAP kinase signaling pathways affects various cellular processes. | ||||||