IL-1RAcP Activators
IL-1RAcP activators represent a diverse group of chemicals that can directly or indirectly enhance the function of IL-1RAcP, influencing anti-inflammatory signaling pathways. Among these activators, Honokiol directly activates IL-1RAcP by promoting the expression of its antagonist, IL-1RA, resulting in the downregulation of inflammatory responses. Resveratrol, an indirect activator, modulates IL-1RAcP through the SIRT1 pathway, emphasizing the interconnectedness between cellular processes and IL-1RAcP activation. Additionally, compounds like Celastrol, Oleanolic Acid, and Arachidonic Acid demonstrate indirect activation by targeting NRF2, Nrf2, and the COX-2/PGE2 pathway, respectively. These pathways contribute to the upregulation of IL-1RA expression and subsequent IL-1RAcP activation, providing potential strategies for anti-inflammatory interventions. Maresin-1 and Lithocholic Acid showcase indirect activation through the ALX/FPR2 and FXR pathways, respectively, linking resolution of inflammation and bile acid signaling to IL-1RAcP function.
Moreover, compounds such as 15-Deoxy-Δ12,14-Prostaglandin J2, Luteolin, and Thymoquinone exert indirect activation by targeting PPARγ, NF-κB, and Nrf2 pathways, respectively. These compounds illustrate the intricate regulatory networks involved in IL-1RAcP-mediated anti-inflammatory responses. Additionally, Baicalein, Salvianolic Acid A, and Ginsenoside Rg1 act as indirect activators by influencing the JAK/STAT, MAPK, and PI3K/Akt pathways, respectively, underscoring the versatility of IL-1RAcP activation in mitigating immune responses and inflammation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Honokiol | 35354-74-6 | sc-202653 sc-202653A | 10 mg 25 mg | $118.00 $178.00 | 4 | |
Honokiol is a direct activator of IL-1RAcP by promoting anti-inflammatory signaling pathways. It enhances the expression of IL-1RA, an antagonist of IL-1, leading to the activation of IL-1RAcP and subsequent downregulation of inflammatory responses. Honokiol modulates cellular processes by influencing the balance between IL-1 and IL-1RA, promoting anti-inflammatory effects associated with IL-1RAcP activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol acts as an indirect IL-1RAcP activator by targeting the SIRT1 pathway. It enhances SIRT1 activity, leading to the deacetylation and activation of IL-1RAcP. This modulation promotes anti-inflammatory signaling, influencing cellular responses associated with IL-1RAcP activation. Resveratrol's indirect activation of IL-1RAcP through the SIRT1 pathway highlights its potential as a natural compound with anti-inflammatory properties. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol acts as an indirect IL-1RAcP activator by targeting the NRF2 pathway. It enhances NRF2 activation, leading to the upregulation of IL-1RA expression and subsequent activation of IL-1RAcP. Celastrol modulates cellular processes by influencing antioxidant responses associated with IL-1RAcP activation, providing a potential avenue for mitigating oxidative stress and inflammation. | ||||||
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $86.00 $302.00 | 8 | |
Oleanolic Acid serves as an indirect IL-1RAcP activator by modulating the Nrf2 pathway. It enhances Nrf2 activation, leading to the upregulation of IL-1RA expression and subsequent activation of IL-1RAcP. Oleanolic Acid influences cellular processes by promoting antioxidant responses associated with IL-1RAcP activation, suggesting its potential in addressing oxidative stress and inflammation. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic Acid is a direct IL-1RAcP activator through the COX-2/PGE2 pathway. It induces the expression of COX-2, leading to increased PGE2 production and subsequent activation of IL-1RAcP. Arachidonic Acid modulates cellular processes by promoting anti-inflammatory signaling associated with IL-1RAcP activation, highlighting its role in the regulation of immune responses and inflammation. | ||||||
Lithocholic acid | 434-13-9 | sc-215262 sc-215262A | 10 g 25 g | $100.00 $272.00 | 1 | |
Lithocholic Acid is an indirect IL-1RAcP activator through the FXR pathway. It activates FXR, leading to the upregulation of IL-1RA expression and subsequent activation of IL-1RAcP. Lithocholic Acid modulates cellular processes by influencing bile acid signaling associated with IL-1RAcP activation, providing insights into the potential crosstalk between metabolic and inflammatory pathways. | ||||||
15-Deoxy-δ12,14-Prostaglandin J2 | 87893-55-8 | sc-201262 sc-201262A | 1 mg 5 mg | $141.00 $551.00 | 5 | |
15-Deoxy-Δ12,14-Prostaglandin J2 acts as an indirect IL-1RAcP activator by targeting the PPARγ pathway. It activates PPARγ, leading to the upregulation of IL-1RA expression and subsequent activation of IL-1RAcP. This compound modulates cellular processes by promoting anti-inflammatory signaling associated with IL-1RAcP activation, suggesting its potential in regulating immune responses and inflammation. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin is an indirect IL-1RAcP activator by targeting the NF-κB pathway. It inhibits NF-κB activation, leading to the downregulation of pro-inflammatory cytokines and subsequent activation of IL-1RAcP. Luteolin modulates cellular processes by influencing anti-inflammatory signaling associated with IL-1RAcP activation, suggesting its potential in mitigating immune responses and inflammation. | ||||||
Thymoquinone | 490-91-5 | sc-215986 sc-215986A | 1 g 5 g | $47.00 $133.00 | 21 | |
Thymoquinone serves as a direct IL-1RAcP activator by targeting the Nrf2 pathway. It enhances Nrf2 activation, leading to the upregulation of IL-1RA expression and subsequent activation of IL-1RAcP. Thymoquinone modulates cellular processes by promoting antioxidant responses associated with IL-1RAcP activation, providing potential avenues for addressing oxidative stress and inflammation. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Baicalein acts as an indirect IL-1RAcP activator by targeting the JAK/STAT pathway. It inhibits JAK/STAT activation, leading to the downregulation of pro-inflammatory cytokines and subsequent activation of IL-1RAcP. Baicalein modulates cellular processes by influencing anti-inflammatory signaling associated with IL-1RAcP activation, suggesting its potential in mitigating immune responses and inflammation. | ||||||