IL-1RAcP Activators

IL-1RAcP activators represent a diverse group of chemicals that can directly or indirectly enhance the function of IL-1RAcP, influencing anti-inflammatory signaling pathways. Among these activators, Honokiol directly activates IL-1RAcP by promoting the expression of its antagonist, IL-1RA, resulting in the downregulation of inflammatory responses. Resveratrol, an indirect activator, modulates IL-1RAcP through the SIRT1 pathway, emphasizing the interconnectedness between cellular processes and IL-1RAcP activation. Additionally, compounds like Celastrol, Oleanolic Acid, and Arachidonic Acid demonstrate indirect activation by targeting NRF2, Nrf2, and the COX-2/PGE2 pathway, respectively. These pathways contribute to the upregulation of IL-1RA expression and subsequent IL-1RAcP activation, providing potential strategies for anti-inflammatory interventions. Maresin-1 and Lithocholic Acid showcase indirect activation through the ALX/FPR2 and FXR pathways, respectively, linking resolution of inflammation and bile acid signaling to IL-1RAcP function.

Moreover, compounds such as 15-Deoxy-Δ12,14-Prostaglandin J2, Luteolin, and Thymoquinone exert indirect activation by targeting PPARγ, NF-κB, and Nrf2 pathways, respectively. These compounds illustrate the intricate regulatory networks involved in IL-1RAcP-mediated anti-inflammatory responses. Additionally, Baicalein, Salvianolic Acid A, and Ginsenoside Rg1 act as indirect activators by influencing the JAK/STAT, MAPK, and PI3K/Akt pathways, respectively, underscoring the versatility of IL-1RAcP activation in mitigating immune responses and inflammation.