GABAA R α 1 Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CL 218872 | 66548-69-4 | sc-203552 sc-203552A | 10 mg 50 mg | $85.00 $319.00 | ||
CL 218872 acts as a selective modulator of the GABA receptor alpha 1 subtype, showcasing a unique binding profile that enhances receptor sensitivity. Its molecular interactions involve specific hydrogen bonding and hydrophobic contacts, which stabilize the receptor's active conformation. This compound influences ion channel kinetics, resulting in altered neurotransmission dynamics. The distinct pathway it engages may lead to nuanced effects on synaptic plasticity and neuronal excitability. | ||||||
TB 21007 | 207306-50-1 | sc-204322 sc-204322A | 10 mg 50 mg | $172.00 $729.00 | ||
TB 21007 functions as a selective modulator of the GABA receptor alpha 1 subtype, exhibiting a unique affinity that promotes receptor activation. Its interactions are characterized by precise electrostatic and van der Waals forces, which facilitate a conformational shift in the receptor. This compound alters the kinetics of ion flow through the channel, potentially impacting synaptic signaling and influencing neuronal network behavior in a distinctive manner. | ||||||
Muscimol | 2763-96-4 | sc-200460 sc-200460A | 5 mg 25 mg | $161.00 $537.00 | 2 | |
Muscimol is a potent GABA_A receptor agonist that preferentially binds to the GABA binding site on the GABA_A Rα1, mimicking the effects of GABA and facilitating an increase in chloride ion conductance, thus enhancing the receptor's activity. | ||||||
L-838417 | 286456-42-6 | sc-211693 sc-211693A sc-211693B sc-211693C sc-211693D | 5 mg 10 mg 100 mg 500 mg 1 g | $249.00 $430.00 $3000.00 $13500.00 $19500.00 | ||
L-838417 acts as a selective allosteric modulator of the GABA receptor alpha 1 subtype, demonstrating a unique binding profile that enhances receptor sensitivity. Its molecular interactions involve hydrogen bonding and hydrophobic contacts, leading to a stabilization of the receptor's active conformation. This modulation affects the kinetics of chloride ion influx, thereby influencing the overall excitability of neuronal circuits and contributing to distinct synaptic dynamics. | ||||||
Isoflurane | 26675-46-7 | sc-470926 sc-470926A | 5 g 25 g | $69.00 $219.00 | 7 | |
Isoflurane acts as a positive allosteric modulator of the GABA_A receptor. It sensitizes the receptor to GABA, particularly the isoforms containing the α1 subunit, and thus enhances the function of GABA_A Rα1. | ||||||
Etomidate | 33125-97-2 | sc-203577 | 10 mg | $126.00 | ||
Etomidate is an intravenous anesthetic that acts by potentiating GABAergic neurotransmission. It selectively enhances GABA-induced chloride currents, especially in receptors containing the α1 subunit, thus positively modulating GABA_A Rα1. | ||||||