Molecular structure of L-838417, CAS Number: 286456-42-6
L-838417 (CAS 286456-42-6)
Application:
L-838417 is a subtype-selective GABAA receptor partial agonist
CAS Number:
286456-42-6
Molecular Weight:
399.40
Molecular Formula:
C19H19F2N7O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
A selective ligand for GABAA receptors.
L-838417 (CAS 286456-42-6) References
- Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. | McKernan, RM., et al. 2000. Nat Neurosci. 3: 587-92. PMID: 10816315
- Rodent pharmacokinetics and receptor occupancy of the GABAA receptor subtype selective benzodiazepine site ligand L-838417. | Scott-Stevens, P., et al. 2005. Biopharm Drug Dispos. 26: 13-20. PMID: 15578749
- Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates. | Rowlett, JK., et al. 2005. Proc Natl Acad Sci U S A. 102: 915-20. PMID: 15644443
- Effects of benzodiazepines receptor agonists on the hypothalamic-pituitary-adrenocortical axis. | Mikkelsen, JD., et al. 2005. Eur J Pharmacol. 519: 223-30. PMID: 16125698
- Differential behavioral effects of low efficacy positive GABAA modulators in combination with benzodiazepines and a neuroactive steroid in rhesus monkeys. | McMahon, LR. and France, CP. 2006. Br J Pharmacol. 147: 260-8. PMID: 16331290
- Comparative cue generalization profiles of L-838, 417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination. | Mirza, NR., et al. 2006. J Pharmacol Exp Ther. 316: 1291-9. PMID: 16339395
- Pharmacological and computational analysis of alpha-subunit preferential GABA(A) positive allosteric modulators on the rat septo-hippocampal activity. | Ujfalussy, B., et al. 2007. Neuropharmacology. 52: 733-43. PMID: 17113111
- Reversal of pathological pain through specific spinal GABAA receptor subtypes. | Knabl, J., et al. 2008. Nature. 451: 330-4. PMID: 18202657
- Strain- and model-dependent effects of chlordiazepoxide, L-838,417 and zolpidem on anxiety-like behaviours in laboratory mice. | Mathiasen, LS., et al. 2008. Pharmacol Biochem Behav. 90: 19-36. PMID: 18321566
- [Effect of L-838,417 on pain behavior in a rat model of trigeminal neuralgia]. | Gong, Z. and Xiong, YC. 2011. Nan Fang Yi Ke Da Xue Xue Bao. 31: 890-3. PMID: 21602151
- Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function. | Hofmann, M., et al. 2012. Behav Pharmacol. 23: 790-801. PMID: 23075708
- Enhancement of inhibitory neurotransmission by GABAA receptors having α2,3-subunits ameliorates behavioral deficits in a mouse model of autism. | Han, S., et al. 2014. Neuron. 81: 1282-1289. PMID: 24656250
- Selective stimulation of central GABAAα2,3,5 receptors increases intake and motivation to consume sucrose solution in rats. | Nelson, TS., et al. 2019. Neuroscience. 409: 111-119. PMID: 31047979
- Self-administration of benzodiazepine and cocaine combinations by male and female rhesus monkeys in a choice procedure: role of α1 subunit-containing GABAA receptors. | Huskinson, SL., et al. 2019. Psychopharmacology (Berl). 236: 3271-3279. PMID: 31183518
Inhibitor of:
GABAA Rα6.Activator of:
GABAA R α 1, GABAA R α 2, GABAA R α 3, and GABAA R α 5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-838417, 5 mg | sc-211693 | 5 mg | $249.00 | |||
L-838417, 10 mg | sc-211693A | 10 mg | $430.00 | |||
L-838417, 100 mg | sc-211693B | 100 mg | $3000.00 | |||
L-838417, 500 mg | sc-211693C | 500 mg | $13500.00 | |||
L-838417, 1 g | sc-211693D | 1 g | $19500.00 |