TB 21007 CAS: 207306-50-1
MF: C15H17NO2S3
MW: 339.5
A GABAA receptor inverse agonist.

TB 21007 (CAS 207306-50-1)

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Alternate Names: 6,7-Dihydro-3-[(2-hydroxyethyl)thio]-6,6-dimethyl-1-(2-thiazolyl)-benzo[c]thiophen-4(5H)-one
Application: TB 21007 is a GABAA receptor inverse agonist
CAS Number: 207306-50-1
Purity: >99%
Molecular Weight: 339.5
Molecular Formula: C15H17NO2S3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

TB 21007 is a GABAA receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for GABAA α5, GABAA α2, GABAA α1 and GABAA α3 subtypes respectively).


References

Chambers et al (2003) Identification of a novel, selective GABA5 a5 receptor inverse agonist which enhances cognition. J.Med.Chem. 46 2227.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (25 mM).
Storage :
Store at 4° C
Melting Point :
212.97° C (Predicted)
Boiling Point :
~544.9° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
Ki Data :
GABAA R α5 subtypes: Ki= 1.6 nM; GABAA R α2 subtypes: Ki= 16 nM; GABAA R α1 subtypes: Ki= 20 nM; GABAA R α3 subtypes: Ki= 20 nM
pK Values :
pKb: 1.53 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6918633
MDL Number :
MFCD10687100
SMILES :
CC1(CC2=C(SC(=C2C(=O)C1)SCCO)C3=NC=CS3)C

Download SDS (MSDS)

Certificate of Analysis

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