Molecular structure of TB 21007, CAS Number: 207306-50-1
TB 21007 (CAS 207306-50-1)
Alternate Names:
6,7-Dihydro-3-[(2-hydroxyethyl)thio]-6,6-dimethyl-1-(2-thiazolyl)-benzo[c]thiophen-4(5H)-one
Application:
TB 21007 is a GABAA receptor inverse agonist
CAS Number:
207306-50-1
Purity:
>99%
Molecular Weight:
339.5
Molecular Formula:
C15H17NO2S3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
GABAA receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subtypes respectively). Brain penetrant; enhances cognitive performance in rats in the delayed matching-to-place morris water maze test following i.p. administration.
TB 21007 (CAS 207306-50-1) References
- Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition. | Chambers, MS., et al. 2003. J Med Chem. 46: 2227-40. PMID: 12747794
- Α2 GABAA receptor sub-units in the ventral hippocampus and α5 GABAA receptor sub-units in the dorsal hippocampus mediate anxiety and fear memory. | McEown, K. and Treit, D. 2013. Neuroscience. 252: 169-77. PMID: 23962649
- Physiological and pharmacological properties of inhibitory postsynaptic currents mediated by α5β1γ2, α5β2γ2 and α5β3γ2 GABAA receptors. | Chen, X., et al. 2017. Neuropharmacology. 125: 243-253. PMID: 28757051
- Blockade of spinal α5-GABAA receptors differentially reduces reserpine-induced fibromyalgia-type pain in female rats. | De la Luz-Cuellar, YE., et al. 2019. Eur J Pharmacol. 858: 172443. PMID: 31181208
- Psychotropic Drugs for the Management of Chronic Pain and Itch. | Belinskaia, DA., et al. 2019. Pharmaceuticals (Basel). 12: PMID: 31238561
- Relocation of an Extrasynaptic GABAA Receptor to Inhibitory Synapses Freezes Excitatory Synaptic Strength and Preserves Memory. | Davenport, CM., et al. 2021. Neuron. 109: 123-134.e4. PMID: 33096025
- Therapeutic Approaches to Nociplastic Pain Based on Findings in the Reserpine-Induced Fibromyalgia-Like Animal Model. | Nagakura, Y. 2022. J Pharmacol Exp Ther. 381: 106-119. PMID: 35246482
Activator of:
GABAA R α 1, GABAA R α 2, GABAA R α 3, and GABAA R α 5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TB 21007, 10 mg | sc-204322 | 10 mg | $169.00 | |||
| US: Only available in the US | ||||||
TB 21007, 50 mg | sc-204322A | 50 mg | $715.00 | |||
| US: Only available in the US | ||||||