ZZZ3 Activators
ZZZ3 Activators are a curated set of chemical entities that enhance the functional capacity of ZZZ3 through distinct yet interrelated signaling pathways. Forskolin, a diterpenoid, plays a pivotal role by increasing intracellular cAMP levels, thereby indirectly potentiating ZZZ3's activity through PKA-mediated phosphorylation of associated substrates. This mechanism provides a conducive environment for ZZZ3 to perform its functions effectively. Similarly, PMA, through its role as an activator of PKC, fosters a signaling milieu that augments ZZZ3's activity by phosphorylating intermediary proteins directly involved in ZZZ3's regulatory network. IBMX, with its ability to elevate cAMP and cGMP levels, amplifies PKA and PKG pathways, subsequently enhancing the activity of ZZZ3 by facilitating the phosphorylation of factors that interact with ZZZ3. EGCG contributes by inhibiting kinases that normally phosphorylate proteins that act as negative regulators of ZZZ3, thus indirectly sustaining ZZZ3's active state.
The cascade of influences on ZZZ3 does not halt with kinase modulation; phosphodiesterase inhibitors like Sildenafil Citrate elevate cGMP, which in turn activates PKG and positively influences ZZZ3's activity through phosphorylation-driven signaling cascades. A23187, through its role as a calcium ionophore, escalates intracellular calcium levels, which activates calcium-dependent kinases that phosphorylate and regulate proteins pivotal for ZZZ3's role in cellular signaling. Y-27632, by inhibiting ROCK, rewires the cellular signaling architecture, leading to an enhanced role of ZZZ3 in cell stress response and cytoskeletal organization. Lastly, 8-Bromo-cAMP and Trichostatin A, by mimicking cAMP effects and inhibiting histone deacetylases, respectively, secure an upsurge in ZZZ3 activity through increased PKA activity and altered chromatin states conducive to ZZZ3's action.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a labdane diterpenoid that activates adenylyl cyclase, leading to increased production of cAMP in cells. Elevated cAMP levels can enhance ZZZ3 activity by stimulating protein kinase A (PKA), which may phosphorylate substrates that interact with or modify ZZZ3 function, thus promoting its activation in cellular signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). By activating PKC, PMA influences signaling pathways that modulate the activity of ZZZ3. PKC can phosphorylate proteins that are either part of the ZZZ3 complex or regulate its activity, thereby enhancing the functional activity of ZZZ3 in processes such as chromatin remodeling and gene expression regulation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which increases intracellular cAMP and cGMP by preventing their degradation. This leads to the activation of PKA and PKG, respectively, which may enhance ZZZ3 activity by phosphorylating factors that modulate ZZZ3's role in its specific signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a catechin found in green tea with kinase inhibitory activity. It can modulate various signaling pathways by inhibiting kinases that would otherwise phosphorylate proteins that negatively regulate ZZZ3, thus indirectly increasing the functional activity of ZZZ3 by preventing its deactivation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent kinases such as calmodulin kinase, which may enhance ZZZ3 activity by phosphorylating proteins that regulate ZZZ3 function in its signaling pathways, therefore facilitating its functional activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of ROCK (Rho-associated, coiled-coil containing protein kinase). Inhibition of ROCK can lead to altered actin cytoskeleton dynamics and influence signaling pathways that ZZZ3 is a part of, leading to enhanced functional activity of ZZZ3 in processes related to cell structure and gene expression. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. By activating PKA, it can phosphorylate substrates that modulate ZZZ3 activity, leading to enhanced functional activity of ZZZ3 in its signaling pathways including transcriptional regulation and chromatin remodeling. | ||||||