ZSCAN2 Inhibitors
ZSCAN2 inhibitors belong to a specialized category of chemical compounds designed to modulate the activity of the ZSCAN2 gene. The ZSCAN2 gene, also known as zinc finger and SCAN domain-containing 2, plays a crucial role in the regulation of cellular processes, particularly in the context of cellular differentiation and maintenance of genomic stability. The inhibitors targeting ZSCAN2 function are meticulously crafted to interfere with the normal activity of this gene, influencing downstream molecular pathways and cellular functions.
Chemically, ZSCAN2 inhibitors are designed to interact with specific binding sites or domains within the ZSCAN2 protein, disrupting its normal function. These inhibitors may operate through various mechanisms, such as blocking enzymatic activity, altering protein-protein interactions, or modulating gene expression patterns associated with ZSCAN2. By doing so, they can exert a regulatory influence on cellular processes that are tightly controlled by ZSCAN2, offering a valuable tool for researchers to explore the intricate mechanisms governing cell fate determination and genomic integrity. The development and study of ZSCAN2 inhibitors contribute to advancing our understanding of molecular biology, providing insights into the intricate web of cellular pathways that orchestrate fundamental biological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that prevents the degradation of ubiquitinated proteins. Inhibiting the proteasome can lead to the accumulation of regulatory proteins that might otherwise degrade ZSCAN2, potentially reducing its functional activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. By reducing methylation levels, it can alter the expression patterns of genes, including potentially reducing the expression of ZSCAN2 if its promoter region is subject to methylation-based control. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an inhibitor of histone deacetylases (HDACs). HDAC inhibition can result in altered chromatin structure and could conceivably decrease ZSCAN2 expression by affecting the acetylation status of histones near its gene locus. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. By inhibiting PI3K, it impedes the PI3K/AKT signaling pathway which is involved in various cellular processes, including transcriptional regulation. This may indirectly decrease ZSCAN2 activity by affecting pathways regulating its expression. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that by blocking MEK1/2 prevents the activation of ERK1/2 in the MAPK pathway. This pathway influences gene expression and could indirectly result in decreased ZSCAN2 activity due to lowered transcriptional activation. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
CHIR99021 is a GSK-3 inhibitor. Inhibition of GSK-3 could disrupt Wnt signaling, leading to changes in gene expression patterns which might include downregulation of ZSCAN2 expression in certain cellular contexts. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is an inhibitor of the TGF-β receptor. TGF-β signaling affects a wide array of genes and cellular processes including differentiation and proliferation, potentially impacting ZSCAN2 expression indirectly. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor, which can lead to changes in cell growth and proliferation signals. By inhibiting mTOR, rapamycin could indirectly reduce ZSCAN2 activity by affecting cellular processes that utilize ZSCAN2. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 is an MDM2 antagonist that stabilizes p53. The activation of p53 can lead to alterations in gene expression, including potential downregulation of ZSCAN2 as part of a p53-mediated stress response. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine is a Hedgehog pathway inhibitor, which could potentially reduce ZSCAN2 expression by affecting the transcription factors regulated by this pathway, assuming a regulatory relationship between the Hedgehog pathway and ZSCAN2 expression. | ||||||