ZnT-1 Inhibitors
The class of ZnT-1 inhibitors, in the context of indirect inhibition, includes a variety of compounds that primarily target zinc homeostasis and metal ion chelation. ZnT-1 functions to regulate the efflux of zinc from cells, and its activity is influenced by the intracellular concentration of zinc. Compounds like TPEN, Clioquinol, EDTA, EGTA, Dithizone, Histidine, and Sodium Diethyldithiocarbamate, which can chelate zinc and other metal ions, may indirectly impact ZnT-1 by altering the availability of its substrate, zinc. By modulating intracellular zinc levels, these chelators can influence the regulatory mechanisms that control ZnT-1 activity.
Additionally, compounds that disrupt metal ion homeostasis, such as Zinc Pyrithione, Cadmium Chloride, and Mercury Chloride, can also indirectly affect ZnT-1. These compounds, by increasing or interfering with intracellular metal concentrations, could create an imbalance that necessitates the compensatory activity of zinc transporters, including ZnT-1. Disulfiram and Pyrrolidine Dithiocarbamate, known for their metal-chelating properties, represent additional mechanisms by which ZnT-1 function can be modulated indirectly
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Clioquinol | 130-26-7 | sc-201066 sc-201066A | 1 g 5 g | $44.00 $113.00 | 2 | |
Metal chelator, can chelate zinc, potentially influencing ZnT-1 activity. | ||||||
EGTA | 67-42-5 | sc-3593 sc-3593A sc-3593B sc-3593C sc-3593D | 1 g 10 g 100 g 250 g 1 kg | $20.00 $62.00 $116.00 $246.00 $799.00 | 23 | |
Calcium chelator that may indirectly affect zinc homeostasis and ZnT-1 activity. | ||||||
Dithizone | 60-10-6 | sc-206031A sc-206031 | 10 g 50 g | $90.00 $332.00 | 2 | |
Zinc chelator, can influence zinc availability and potentially ZnT-1 activity. | ||||||
L-Histidine | 71-00-1 | sc-394101 sc-394101A sc-394101B sc-394101C sc-394101D | 25 g 100 g 250 g 500 g 1 kg | $53.00 $82.00 $185.00 $200.00 $332.00 | 1 | |
Can bind zinc ions, potentially influencing cellular zinc levels and ZnT-1 activity. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Aldehyde dehydrogenase inhibitor, known to chelate metals and may affect ZnT-1. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $32.00 $63.00 | 11 | |
A metal chelator and antioxidant, potentially affecting zinc homeostasis and ZnT-1. | ||||||
Diethyldithiocarbamic acid sodium salt trihydrate | 20624-25-3 | sc-202576 sc-202576A | 5 g 25 g | $19.00 $58.00 | 2 | |
Chelates various metal ions, could influence zinc homeostasis and ZnT-1 activity. | ||||||