ZNHIT2 Inhibitors
ZNHIT2 inhibitors encompass a spectrum of compounds that, through various biochemical mechanisms, lead to the functional inhibition of the ZNHIT2 protein. ZNHIT2 plays a critical role in pre-mRNA splicing, which is a fundamental process for gene expression and regulation. Compounds such as Heparin, Pladienolide B, and E7107 target the spliceosome, the complex that facilitates splicing, thereby impacting ZNHIT2's role within this complex. Heparin disrupts protein-RNA interactions, which are crucial for the spliceosome's assembly and operation, and where ZNHIT2 serves essential functions. Pladienolide B and E7107 target the SF3B complex of the spliceosome, a direct interaction point for ZNHIT2 during the splicing process. By inhibiting SF3B, these compounds indirectly inhibit ZNHIT2 by dismantling the very machinery in which it operates.
Other compounds like Chloroquine and Suramin interfere with nucleic acid stability and protein-nucleic acid interactions, respectively. Chloroquine's ability to destabilize nucleic acids can prevent ZNHIT2 from engaging in necessary interactions within the spliceosome, leading to an inhibition of its function. Similarly, Suramin's binding to nucleic acids can obstruct ZNHIT2's RNA-related activities. Madrasin and Isoginkgetin disrupt other essential components and processes of the spliceosome, indirectly leading to ZNHIT2 inhibition by depriving it of its functional platform. Amiloride and Bortezomib, though not directly connected to splicing, can influence cellular conditions and stress responses that secondarily affect spliceosome assembly.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Heparin is an anticoagulant that interferes with the coagulation cascade. The interaction between ZNHIT2 and components of the spliceosome is essential for pre-mRNA splicing. Heparin is known to disrupt protein-nucleic acid interactions. By binding to the spliceosome, heparin could inhibit the functional activity of ZNHIT2 by preventing its proper interaction with the spliceosome complex. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
Pladienolide B is a spliceosome inhibitor that targets the SF3B complex. Since ZNHIT2 is involved in pre-mRNA splicing by supporting spliceosome functions, the inhibition of SF3B by Pladienolide B would indirectly inhibit the functional activity of ZNHIT2 by disrupting the splicing machinery where ZNHIT2 operates. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is an antimalarial drug that also has an effect on nucleic acid stabilization. By altering the stability of nucleic acids, Chloroquine could interfere with the RNA-protein interactions necessary for ZNHIT2 to function in the spliceosome, indirectly inhibiting its activity. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin is a polysulfonated naphthylurea that inhibits various enzymes, and it can bind to nucleic acids. Its interaction with RNA could disturb the normal function of ZNHIT2 within the spliceosome by preventing the necessary RNA-protein interactions for splicing. | ||||||
Madrasin | 374913-63-0 | sc-507563 | 100 mg | $750.00 | ||
Madrasin is a splicing inhibitor that specifically targets the splicing factor Prp19 complex. ZNHIT2, being associated with pre-mRNA splicing and the spliceosome, would have its function inhibited as Madrasin disrupts the Prp19 complex which is necessary for the splicing cycle where ZNHIT2 is active. | ||||||
Isoginkgetin | 548-19-6 | sc-507430 | 5 mg | $225.00 | ||
Isoginkgetin is a pre-mRNA splicing inhibitor that affects spliceosome assembly. By inhibiting spliceosome assembly, Isoginkgetin indirectly inhibits ZNHIT2's activity since ZNHIT2 functions within the assembled spliceosome complex. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $57.00 | 6 | |
Amiloride is a potassium-sparing diuretic that also inhibits urokinase-type plasminogen activator receptor (uPAR). By inhibiting uPAR, Amiloride may affect cellular signaling pathways that influence RNA processing events, thereby indirectly inhibiting ZNHIT2's function in splicing. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor. While its primary action is on proteasome activity, the accumulation of misfolded proteins can lead to cellular stress and potentially affect the assembly of protein complexes such as the spliceosome, indirectly inhibiting ZNHIT2's function. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $57.00 $77.00 | 2 | |
Ivermectin is an antiparasitic agent that has been shown to inhibit importin α/β1 heterodimer formation, which is crucial for nuclear transport. If nuclear transport is inhibited, this could affect the localization and function of ZNHIT2 in the spliceosome indirectly. | ||||||