ZNF763 Activators
Chemical activators of ZNF763 include a variety of compounds that influence different signaling pathways within the cell, leading to the phosphorylation and subsequent activation of this protein. Phorbol 12-myristate 13-acetate (PMA) can activate ZNF763 by stimulating protein kinase C (PKC), which phosphorylates an array of target proteins. Forskolin exerts its effect by activating adenylyl cyclase, increasing intracellular cyclic AMP (cAMP), which in turn activates protein kinase A (PKA). PKA, like PKC, can phosphorylate and activate proteins, including ZNF763 if it is among its substrates. Ionomycin, by acting as a calcium ionophore, raises intracellular calcium levels, which can bind to calmodulin and activate calmodulin-dependent kinases (CaMK). This cascade may lead to the phosphorylation of ZNF763 if it is a target of CaMK.
Further chemical activators include Thapsigargin, which disrupts calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), possibly leading to the activation of ZNF763 through calcium-dependent kinases. Calyculin A and Okadaic Acid, both inhibitors of protein phosphatases 1 and 2A, can prevent the dephosphorylation of proteins, potentially maintaining ZNF763 in an activated state if it is regulated by phosphorylation. Anisomycin activates stress-activated protein kinases (SAPKs), which may phosphorylate ZNF763, while Staurosporine, at low concentrations, can activate certain kinase pathways that might phosphorylate and activate ZNF763. Dibutyryl-cAMP, a cAMP analog, activates PKA, which could lead to the phosphorylation of ZNF763. Lastly, H-89, known as an inhibitor of PKA, can modulate other kinases that, depending on the cellular context, may result in the activation of ZNF763. Each of these chemicals can influence the phosphorylation state of ZNF763 through their respective targets and pathways, leading to the protein's activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which is known to phosphorylate a wide array of target proteins. Since PKC-mediated phosphorylation is a common post-translational modification that regulates protein function, PKC activation by PMA can lead to the phosphorylation and subsequent activation of ZNF763, assuming ZNF763 is a substrate for PKC. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, which increases levels of cyclic AMP (cAMP) in cells. Elevated cAMP activates protein kinase A (PKA), and PKA can phosphorylate a multitude of proteins. If ZNF763 is among the substrates of PKA, then forskolin, by raising cAMP levels and activating PKA, can lead to the functional activation of ZNF763 through phosphorylation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as an ionophore for calcium, increasing intracellular calcium levels. Calcium binds to calmodulin, which then activates calmodulin-dependent kinases (CaMK). CaMK can phosphorylate various proteins within the cell. Should ZNF763 be a target for CaMK, the ionomycin-induced increase in intracellular calcium would result in the activation of CaMK and potentially the phosphorylation and activation of ZNF763. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytoplasmic calcium levels. This rise in calcium can activate calcium-dependent signaling pathways, such as those mediated by CaMK. If ZNF763 is a protein that is regulated by calcium-dependent phosphorylation, thapsigargin-induced calcium elevation could result in the activation of ZNF763. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A inhibits protein phosphatases 1 and 2A, leading to increased phosphorylation of proteins by preventing their dephosphorylation. This inhibition can lead to a sustained activation state of proteins that are regulated by phosphorylation. Thus, if ZNF763's activation state is regulated by phosphorylation, the inhibition of its dephosphorylation by Calyculin A can result in its activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid, like Calyculin A, is an inhibitor of protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, Okadaic Acid can maintain proteins in a phosphorylated state. If ZNF763 function is controlled by phosphorylation, its activity could be upregulated by Okadaic Acid through the prevention of dephosphorylation, thus keeping ZNF763 in an activated state. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is known to activate stress-activated protein kinases (SAPKs), such as JNK. If ZNF763 is a substrate for modification by SAPKs, the activation of these kinases by Anisomycin could lead to the phosphorylation and activation of ZNF763. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine, although primarily a kinase inhibitor, can non-specifically activate certain kinase pathways at low concentrations. If ZNF763 is subject to regulation by any of the kinases influenced by Staurosporine, this could result in its activation through phosphorylation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP, a membrane-permeable cAMP analog, activates PKA. Upon activation, PKA phosphorylates various proteins within the cell. Assuming ZNF763 is a phosphorylation target of PKA, the activation of PKA by Dibutyryl-cAMP could lead to the phosphorylation and activation of ZNF763. | ||||||