ZNF709 Activators
ZNF709 belongs to the extensive family of zinc finger proteins, critical components in transcriptional regulation. To modulate the activity of such proteins, it's pivotal to target the intricate network of epigenetic modifications that govern gene expression. DNA methylation stands as a dominant player in this context. Chemicals like Decitabine, both DNA methyltransferase, function by attenuating DNA methylation, a modification typically associated with gene silencing. By limiting this repression, these agents can enhance the transcription of genes, including ZNF709, particularly if they're suppressed due to methylation.
Histone modifications further augment the transcriptional orchestra. Agents like VPA and Entinostat, all HDAC strive to increase histone acetylation. Elevated histone acetylation typically promotes an open chromatin state conducive for transcription. ZNF709's transcription is modulated by histone acetylation, these agents can be instrumental. Delving deeper into histone dynamics, BIX-01294 and UNC0638 target histone methylation, another cardinal epigenetic mark. They inhibit specific histone methyltransferases, enzymes responsible for adding methylation marks on histones. By influencing these marks, these chemicals can alter the transcriptional status of genes, including ZNF709, especially if its regulation hinges on histone methylation. Parthenolide's role in modulating the NF-κB pathway also underscores the interconnected nature of transcriptional regulation. As NF-κB is integral in controlling a plethora of genes, chemicals like Parthenolide can affect ZNF709's status indirectly, signifying the multifaceted strategies that can be employed to activate this protein.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $148.00 | 4 | |
A G9a histone methyltransferase inhibitor. Prevents the methylation of histone H3 which can influence the transcriptional landscape, potentially increasing ZNF709 transcription if it's regulated by H3 methylation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Another HDAC inhibitor. By increasing histone acetylation, it can promote transcription. If ZNF709 transcription is suppressed due to histone deacetylation, VPA can reverse this effect. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Similar to 5-Azacytidine, it's a DNA methyltransferase inhibitor. Can reverse gene silencing by reducing DNA methylation, potentially activating ZNF709 if it's under such regulation. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor. Can reactivate genes silenced by methylation. If ZNF709 expression is affected by DNA methylation, RG108 can influence its expression. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $120.00 | 5 | |
An inhibitor of histone methyltransferase SUV39H1. By inhibiting histone methylation, it can change transcriptional profiles, potentially affecting ZNF709 if it's regulated by this mechanism. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
An HDAC inhibitor. Can activate genes by promoting histone acetylation, influencing chromatin structure. If ZNF709 is regulated by histone acetylation, Entinostat can modulate its expression. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
NF-κB pathway inhibitor. Given the interplay between transcription factors and NF-κB, Parthenolide can influence the transcriptional profile, potentially modulating ZNF709 if it's affected by this pathway. | ||||||
M 344 | 251456-60-7 | sc-203124 sc-203124A | 1 mg 5 mg | $107.00 $316.00 | 8 | |
HDAC inhibitor that promotes transcription by influencing histone acetylation. If ZNF709 expression is linked to histone acetylation status, M344 can influence its transcription. | ||||||
UNC0638 | 1255580-76-7 | sc-397012 | 10 mg | $315.00 | ||
A selective G9a and GLP inhibitor. Affects histone methylation which can influence gene transcription. If ZNF709's expression is influenced by histone methylation, UNC0638 can modulate its level. | ||||||