ZNF654 Inhibitors
ZNF654 inhibitors represent a spectrum of chemical entities specifically designed to attenuate the functional activity of this zinc finger protein through distinct yet convergent biochemical mechanisms. Chemicals such as 1H-1,2,4-Triazole, Disulfiram, Clioquinol, and 1-Hydroxypyridine-2-thione zinc salt exploit the metal-binding nature of ZNF654's zinc finger domains. By sequestering zinc ions, these inhibitors disrupt the crucial coordination required for ZNF654's structural stability and its subsequent DNA-binding function, effectively diminishing its role in regulating gene expression. Similarly, 2,2'-Dithiobisbenzamide and Pyrrolidinedithiocarbamic acid ammonium salt engage with zinc ions, potentially destabilizing ZNF654's conformation and thereby its transcriptional regulatory capabilities. On the other hand, compounds like Ellipticine, Chloroquine, and Quinomycin A obstruct ZNF654's DNA interaction through intercalation, which prevents the protein from effectively binding to its specific DNA recognition sites, critically reducing its regulatory influence.
The action of Mithramycin A is particularly targeted as it binds to G-C rich DNA sequences, likely competing with ZNF654's binding preference and inhibiting its activity. Triptolide takes a broader approach, modulating transcription factors indirectly. This suggests that Triptolide might inhibit ZNF654 by reshaping the transcriptional networks and influencing the expression or function of proteins that interact with or regulate ZNF654. Collectively, these inhibitors function to impair ZNF654's activity through direct interaction with the protein or its binding sites, or by altering the cellular environment essential for its function, leading to a comprehensive diminution of ZNF654's role in gene regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1,2,4-Triazole | 288-88-0 | sc-253972 sc-253972A | 25 g 100 g | $35.00 $115.00 | ||
This azole compound can chelate zinc ions, potentially disrupting the zinc finger domains of ZNF654, thereby inhibiting its DNA-binding capability and subsequent transcriptional regulation activities. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can bind to copper and zinc ions, potentially interfering with the metal ion coordination in the zinc finger motifs of ZNF654, leading to a loss of structural integrity and function. | ||||||
Clioquinol | 130-26-7 | sc-201066 sc-201066A | 1 g 5 g | $44.00 $113.00 | 2 | |
Clioquinol has metal ion chelating properties and can sequester zinc ions, which may lead to the destabilization of the zinc finger domains of ZNF654 and diminish its binding to DNA. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Pyrithione Zinc can disrupt zinc homeostasis. By altering zinc availability, it could indirectly lead to a reduction in the functional activity of zinc finger proteins like ZNF654. | ||||||
Ellipticine | 519-23-3 | sc-200878 sc-200878A | 10 mg 50 mg | $142.00 $558.00 | 4 | |
Ellipticine intercalates with DNA and could obstruct the DNA-binding sites of transcription factors such as ZNF654, decreasing its transcriptional regulatory function. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A preferentially binds to G-C rich regions of DNA, potentially competing with ZNF654 for its DNA-binding sites and inhibiting its regulatory functions. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine intercalates into DNA and may inhibit DNA-binding proteins like ZNF654 from interacting with their target sequences, thereby decreasing ZNF654's regulatory activities. | ||||||
Quinomycin A | 512-64-1 | sc-202306 | 1 mg | $163.00 | 4 | |
Quinomycin A is a bifunctional DNA intercalator that binds to DNA at specific sequences and could impede the access of ZNF654 to its DNA recognition sites, diminishing its activity. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $32.00 $63.00 | 11 | |
Pyrrolidinedithiocarbamic acid ammonium salt chelates metal ions and could strip zinc from ZNF654's zinc finger domains, thereby inhibiting its function. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide is known to inhibit the activity of several transcription factors. It may indirectly inhibit ZNF654 by altering the transcriptional landscape and affecting proteins that interact with or regulate ZNF654. | ||||||