ZNF644 Inhibitors
ZNF644 inhibitors constitute a diverse group of compounds that interfere with various cellular and molecular mechanisms to diminish the functional activity of ZNF644. Histone deacetylase inhibitors such as Trichostatin A and Suberoylanilide Hydroxamic Acid induce hyperacetylation of chromatin, disrupting the DNA-binding capabilities of ZNF644 and thus indirectly reducing its regulatory influence on gene expression. DNA methyltransferase inhibitors like 5-Azacytidine and (-)-Epigallocatechin-3-gallate lead to hypomethylation, which can alter gene expression profiles, including those genes modulated by ZNF644, potentially obstructing ZNF644's DNA-binding activity. Similarly, RG 108's inhibition of DNA methylation could also lead to a reduced influence of ZNF644 on gene regulation. Chromatin state modulators such as BIX01294 and Chaetocin target histone lysine methyltransferases and histone methyltransferase SUV39H1, respectively. By altering the histone methylation status, these compounds can impede the accessibility and regulatory function of ZNF644 on its target genes.
Moreover, the influence of ZNF644 on gene expression can be indirectly diminished by compounds that affect other cellular signaling pathways and regulatory proteins. For instance, Disulfiram, by inhibiting histone demethylases, and JQ1, through the displacement of BET bromodomain proteins from chromatin, can modify gene expression in a manner that reduces ZNF644's regulatory role. Parthenolide's inhibition of the NF-κB pathway, PD 0332991's targeting of CDK4/6, and Nutlin-3's stabilization of p53 all induce changes in cellular states and gene expression patterns. These changes could intersect with or inhibit the expression of genes co-regulated by ZNF644, thereby indirectly decreasing its functional activity. Collectively, these inhibitors employ distinct biochemical mechanisms to reduce the gene regulatory functions of ZNF644, ensuring that its activity is diminished without directly altering its expression or requiring upregulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can lead to a hyperacetylated chromatin state. Hyperacetylation may affect the DNA-binding capability of ZNF644 due to altered chromatin structure, thereby indirectly diminishing ZNF644's ability to modulate gene expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine incorporates into DNA and RNA and inhibits DNA methyltransferases, leading to hypomethylation of DNA. This demethylation can affect the chromatin structure and gene expression profile, including genes that ZNF644 may regulate, potentially leading to a reduction in ZNF644's DNA-binding activity. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG 108 is a DNA methyltransferase inhibitor which prevents DNA methylation. Methylation changes can influence the expression of genes, including those that interact with ZNF644, thus indirectly decreasing ZNF644's regulatory effects on gene expression. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX01294 is a histone lysine methyltransferase inhibitor that specifically targets G9a and GLP, which are involved in gene silencing. Inhibition of these enzymes can lead to altered gene expression patterns, potentially impacting genes that are co-regulated by ZNF644, leading to an indirect decrease in ZNF644’s influence on these genes. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
Chaetocin is a selective inhibitor of the histone methyltransferase SUV39H1. By inhibiting SUV39H1, Chaetocin alters histone methylation, affecting the chromatin state and gene expression. This can indirectly affect ZNF644's role in gene regulation by modifying the expression of genes that ZNF644 targets. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can chelate metal ions and has been shown to inhibit the Jumonji family of histone demethylases. This inhibition can lead to altered histone methylation status, potentially impacting gene expression patterns regulated by ZNF644 and diminishing its regulatory role over these genes. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide is known to inhibit NF-κB pathway. Since ZNF644 might regulate genes that are also modulated by NF-κB, the inhibition of this pathway can lead to a decrease in the functional activity of ZNF644 by diminishing the expression of genes that both NF-κB and ZNF644 might co-regulate. | ||||||
PD 0332991 Isethionate | 827022-33-3 | sc-478943 | 1 mg | $300.00 | ||
PD 0332991 is a selective inhibitor of cyclin-dependent kinase 4/6 (CDK4/6). By inhibiting CDK4/6, it may impact cell cycle progression and cellular proliferation, indirectly affecting ZNF644's role in gene regulation by altering the cell state and potentially the expression of genes that ZNF644 regulates. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Nutlin-3 disrupts the interaction between p53 and MDM2, leading to stabilization and activation of p53. The activation of p53 can induce a transcriptional program that may overlap or interfere with ZNF644-regulated genes, thereby diminishing the regulatory role of ZNF644 on its target genes. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid is a histone deacetylase inhibitor that causes an increase in histone acetylation and alters gene expression. This modulation of chromatin structure can indirectly decrease the functional activity of ZNF644 by affecting the accessibility of ZNF644 to its target gene promoters. | ||||||