ZNF579 Activators
The realm of ZNF579 activators centers around the modulation of the transcriptional framework, in light of ZNF579's pivotal role in DNA-binding transcription factor activity and RNA polymerase II specific DNA binding. At the heart of this modulation lies the principle of altering the epigenetic landscape, whether by manipulating DNA methylation patterns or influencing chromatin states. Key players like Azacitidine and RG108, functioning as DNA methyltransferase, undertake the task of reshaping DNA methylation profiles, consequently amplifying the transcriptional activities of vital proteins such as ZNF579. This demethylation creates an environment primed for the effective execution of ZNF579's core functionalities.
In tandem, we recognize the profound role of histone deacetylase (HDAC) in sculpting the chromatin state. Agents such as Sodium Butyrate, Scriptaid, Oxamflatin, Mocetinostat, AR-42, Tubacin, and MS-275 (Entinostat) converge on this front. By endorsing an open chromatin configuration, these HDAC set the stage for transcription factor binding and function. They essentially tailor an environment where ZNF579 can optimally bind to target DNA sequences, steering transcriptional directions. Moreover, molecules like Chaetocin, a histone methyltransferase, and Anacardic Acid, which affects histone acetylation, present additional angles of epigenetic regulation. These intricate mechanisms converge to emphasize the role and activation of ZNF579 within the cellular nucleus.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Histone deacetylase (HDAC) inhibitor. Sodium Butyrate promotes an open chromatin state, which can enhance ZNF579's DNA binding and transcription factor activities by creating a favorable environment for its function. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $64.00 $183.00 | 11 | |
HDAC inhibitor. Scriptaid enhances gene transcription by promoting an open chromatin state, potentially providing an environment conducive for ZNF579 to bind to its target DNA sequences. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
DNA methyltransferase inhibitor. By affecting the DNA methylation landscape, RG108 can potentially increase the transcriptional activities of proteins like ZNF579. | ||||||
Oxamflatin | 151720-43-3 | sc-205960 sc-205960A | 1 mg 5 mg | $151.00 $470.00 | 4 | |
HDAC inhibitor. Oxamflatin influences gene transcription by promoting an open chromatin structure, which can indirectly boost ZNF579's function in binding specific DNA sequences. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
An HDAC inhibitor. Mocetinostat modifies chromatin structure, enabling a state favorable for the function of transcription factors like ZNF579. | ||||||
(S)-HDAC-42 | 935881-37-1 | sc-296364 sc-296364A | 1 mg 5 mg | $96.00 $417.00 | ||
HDAC inhibitor. AR-42 affects gene transcription by influencing chromatin state, potentially enhancing ZNF579's ability to regulate transcription by RNA polymerase II. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
A non-specific inhibitor of histone methyltransferases. Chaetocin can influence chromatin modifications and potentially affect the transcriptional activities of ZNF579. | ||||||
Tris Buffered Saline: 1 L of 1X | sc-362185 | 1 L | $21.00 | 3 | ||
HDAC6 inhibitor. By specifically inhibiting HDAC6, Tubacin can influence the acetylation state of histones, which can indirectly modulate the transcriptional activities of proteins like ZNF579 in the nucleus. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
HDAC inhibitor. MS-275 impacts gene transcription by influencing chromatin state. This modulation can indirectly affect ZNF579's transcriptional regulation and DNA binding activities. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Inhibits p300 and other histone acetyltransferases. By modulating histone acetylation, Anacardic Acid can influence the chromatin structure and potentially support ZNF579's regulatory activities on transcription by RNA polymerase II. | ||||||