ZNF548 Inhibitors
Chemical inhibitors of ZNF548 can impede its function through various molecular pathways. Chelerythrine, for instance, is a robust inhibitor of protein kinase C (PKC), which is essential for the phosphorylation of many proteins, including transcription factors. By inhibiting PKC, chelerythrine can prevent the phosphorylation of ZNF548, leading to its functional inhibition. Similarly, LY333531 acts selectively to inhibit PKCβ, which is potentially involved in the phosphorylation of ZNF548. The targeted action of LY333531 therefore can prevent the activation or modulation of ZNF548 through phosphorylation. GW5074 targets the Raf-1 kinase within the MAPK/ERK pathway, which is known to regulate the activity of transcription factors. By inhibiting Raf-1, GW5074 can prevent the activation of ZNF548 that would typically occur through this pathway.
Further, PD173955 serves to block the Src family kinases, which are implicated in the phosphorylation and subsequent regulation of transcription factors, thus affecting ZNF548's ability to bind DNA or interact with other molecules. Ibrutinib inhibits Bruton's tyrosine kinase, which is part of signaling pathways regulating ZNF548, and its inhibition can disrupt these pathways. SL327 and PD98059 both inhibit MEK, another kinase within the MAPK/ERK pathway. Their action can prevent the regulatory phosphorylation of ZNF548, hence inhibiting its activity. SP600125 inhibits the JNK pathway, which also plays a role in the regulatory phosphorylation of transcription factors like ZNF548. SB431542 inhibits the TGF-β type I receptor ALK5 kinase, involved in TGF-β signaling pathways that can control the function of ZNF548. Triptolide's inhibition of NF-κB can lead to the downstream inhibition of ZNF548, as it may be regulated by NF-κB-dependent signaling. Lastly, rapamycin, an inhibitor of mTOR that regulates protein activity, can lead to the functional inhibition of ZNF548 if it is regulated by the mTOR pathway.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a potent inhibitor of protein kinase C (PKC), a kinase that can phosphorylate ZNF548, potentially affecting its DNA-binding capability. Inhibition of PKC by chelerythrine would lead to reduced phosphorylation and activity of ZNF548. | ||||||
PD 173955 | 260415-63-2 | sc-507378 | 10 mg | $320.00 | ||
PD173955 blocks Src family kinases, which could be involved in the phosphorylation of ZNF548, altering its ability to interact with other molecules or bind to DNA, thus inhibiting its function. | ||||||
Ibrutinib | 936563-96-1 | sc-483194 | 10 mg | $153.00 | 5 | |
Ibrutinib targets Bruton's tyrosine kinase, which is part of signaling pathways that could be involved in the regulation of ZNF548. Inhibition of this kinase can disrupt these pathways, leading to the functional inhibition of ZNF548. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is an inhibitor of Raf-1 kinase, which is a part of the MAPK/ERK pathway. Since this pathway can regulate the activity of transcription factors like ZNF548, inhibiting Raf-1 can lead to the functional inhibition of ZNF548 by preventing its activation through this pathway. | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
SL327 is known to inhibit MEK, which is upstream in the MAPK/ERK pathway that could regulate ZNF548. The inhibition of this pathway by SL327 can thus inhibit the activity of ZNF548 by preventing its phosphorylation and subsequent activation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 inhibits the JNK pathway, which is involved in regulatory processes that can govern the activity of transcription factors like ZNF548. By inhibiting JNK, SP600125 can inhibit the activity of ZNF548 by blocking its regulatory phosphorylation. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is an inhibitor of the TGF-β type I receptor ALK5 kinase, which is involved in TGF-β signaling pathways that could control the function of ZNF548. Inhibition of this kinase by SB431542 can lead to the functional inhibition of ZNF548 by preventing its activity within this signaling pathway. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide inhibits the activity of NF-κB, a transcription factor that can regulate the expression and activity of other transcription factors. Inhibition of NF-κB by triptolide can lead to the downstream inhibition of ZNF548 activity, as it may be regulated by NF-κB-dependent signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, a key kinase in the mTOR signaling pathway that can regulate the activity of various proteins, including transcription factors. If ZNF548 is regulated by the mTOR pathway, the use of rapamycin would result in the functional inhibition of ZNF548. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 specifically inhibits MEK, which is part of the MAPK/ERK pathway. As this pathway can influence the function of transcription factors, the inhibition of MEK by PD98059 can lead to the functional inhibition of ZNF548 by preventing its phosphorylation and activation. | ||||||