ZNF547 Inhibitors
Chemical inhibitors of ZNF547 function by various mechanisms to modulate the activity of this transcription factor. Chelerythrine operates by inhibiting protein kinase C (PKC), which is crucial for the phosphorylation of proteins, including transcription factors like ZNF547. The inhibition of PKC by chelerythrine can lead to a decrease in the phosphorylation status of ZNF547, thereby reducing its ability to bind DNA and regulate gene expression. Similarly, LY333531, as a selective inhibitor of PKCβ, can disrupt signaling pathways that involve PKCβ, which may be essential for the proper functioning of ZNF547. This interference can decrease the functional activity of ZNF547 by preventing its activation or modulation via phosphorylation.
Other inhibitors target different kinases that can indirectly affect the activity of ZNF547. PD173955, for instance, inhibits Src family kinases, which are involved in the phosphorylation of a wide array of proteins, potentially including ZNF547. This can alter the phosphorylation state of ZNF547 and its subsequent DNA-binding capability. Ibrutinib, which targets Bruton's tyrosine kinase, and GW5074, an inhibitor of Raf-1 kinase, can both disrupt signaling pathways that may regulate ZNF547 activity. For example, the MAPK/ERK pathway, which can be inhibited by GW5074 and SL327, is known to modulate transcription factors. If ZNF547 is regulated through this pathway, its activity would be reduced upon inhibition. Further, SP600125 inhibits the JNK pathway, and SB431542 targets the TGF-β pathway, both of which could impact ZNF547's function. Triptolide's inhibition of NF-κB may also reduce the functional interaction of ZNF547 with the transcriptional machinery. Lastly, rapamycin's inhibition of the mTOR pathway can lead to a decrease in ZNF547's activity if mTOR signaling is involved in its regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a potent inhibitor of protein kinase C (PKC), which ZNF547 may utilize for its DNA-binding activity. Inhibiting PKC can lead to the functional inhibition of ZNF547's ability to interact with its target gene sequences. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone is known to inhibit cyclin-dependent kinases (CDKs). If ZNF547's function is tied to cell cycle progression controlled by CDKs, this chemical would inhibit ZNF547's activity linked to those processes. | ||||||
PD 173955 | 260415-63-2 | sc-507378 | 10 mg | $320.00 | ||
PD173955 is an Src family kinase inhibitor. Since Src kinases can phosphorylate a variety of proteins, including transcription factors, inhibition of Src kinases can lead to functional inhibition of ZNF547's phosphorylation status, altering its activity. | ||||||
Ibrutinib | 936563-96-1 | sc-483194 | 10 mg | $153.00 | 5 | |
Ibrutinib is a Bruton's tyrosine kinase inhibitor. As tyrosine kinases can modulate transcription factors, Ibrutinib's action can lead to functional inhibition of ZNF547 by altering its phosphorylation and subsequent DNA-binding activity. | ||||||
GW 5074 | 220904-83-6 | sc-200639 sc-200639A | 5 mg 25 mg | $106.00 $417.00 | 10 | |
GW5074 is an inhibitor of Raf-1 kinase, part of the MAPK/ERK pathway. ZNF547, as a transcription factor, could be regulated via this pathway, and its inhibition by GW5074 would lead to decreased ZNF547 activity. | ||||||
LY-333,531 Hydrochloride | 169939-93-9 | sc-364215 sc-364215A | 1 mg 5 mg | $92.00 $281.00 | 6 | |
LY333531 is a selective inhibitor of protein kinase C beta (PKCβ). If ZNF547 is regulated by PKCβ-mediated signaling, LY333531 would inhibit this pathway, leading to a reduction in ZNF547's functional activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). JNK can influence the activity of various transcription factors, thus inhibition by SP600125 could lead to decreased functional activity of ZNF547. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is a selective inhibitor of the TGF-β type I receptor ALK5, which is involved in SMAD2/3 activation. ZNF547 could be regulated through this pathway, and its inhibition by SB431542 would decrease ZNF547's activity. | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
SL327 is an inhibitor of MEK1/2, which are upstream activators of ERK in the MAPK pathway. Inhibition of this pathway by SL327 may result in the functional inhibition of ZNF547 if it is regulated by ERK signaling. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide is known to inhibit the transcriptional activity of NF-κB. Since ZNF547 is a transcription factor, triptolide's action could inhibit ZNF547's functional interaction with other transcriptional machinery. | ||||||