ZNF418 Inhibitors
Chemical inhibitors of ZNF418 operate through various mechanisms to impede its function. Staurosporine is a broad-spectrum kinase inhibitor that can target kinases responsible for phosphorylating ZNF418, thus preventing its activation and subsequent biological functions. Similarly, wortmannin and LY294002 are phosphoinositide 3-kinase (PI3K) inhibitors. By impeding PI3K, these inhibitors prevent the activation of AKT, a kinase which is potentially involved in phosphorylating proteins that associate with ZNF418, leading to a decrease in ZNF418 activity. Rapamycin, an mTOR inhibitor, disrupts the mTOR signaling pathway, which plays a key role in cell growth and proliferation, and could be involved in regulating ZNF418. By inhibiting mTOR, rapamycin could indirectly impede the functional regulation of ZNF418, leading to an inhibition of its activity.
MEK inhibitors U0126 and PD98059 specifically target the MAPK/ERK pathway, preventing the phosphorylation of ERK which may be necessary for the phosphorylation of proteins that regulate ZNF418 activity. Inhibition by these chemicals would lead to reduced ZNF418 function. JNK inhibitor SP600125 and p38 MAPK inhibitor SB203580 suppress the activity of their respective kinases, potentially obstructing the phosphorylation of substrates that regulate ZNF418, inhibiting its activity. Dasatinib, a Src family kinase inhibitor, and H-89, a protein kinase A (PKA) inhibitor, block the phosphorylation of proteins that may interact with ZNF418, thus reducing its function. Chelerythrine, which inhibits protein kinase C (PKC), can also impede the phosphorylation of regulatory proteins involved with ZNF418. Bortezomib, a proteasome inhibitor, affects protein homeostasis by preventing the degradation of proteins, which might lead to the accumulation of proteins that can negatively impact ZNF418 function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine inhibits a broad spectrum of protein kinases, which could include kinases that phosphorylate ZNF418, thus inhibiting ZNF418's phosphorylation-dependent function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor that would prevent the phosphorylation of AKT, a kinase that can phosphorylate substrates relevant to ZNF418's function, leading to the inhibition of ZNF418's activity through lack of required phosphorylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another PI3K inhibitor that would inhibit AKT activation, thereby reducing phosphorylation of proteins that could interact with ZNF418, eventually leading to the inhibition of ZNF418's function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and proliferation, which may be involved in the functional regulation of ZNF418, inhibiting downstream effects that would otherwise enhance ZNF418 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a MEK1/2 inhibitor which would block the MAPK/ERK pathway, inhibiting the phosphorylation of ERK, a kinase that could phosphorylate proteins that regulate ZNF418, hence inhibiting ZNF418 function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is also a MEK1/2 inhibitor that would block the MAPK/ERK pathway, potentially leading to reduced phosphorylation of proteins that are involved in the functional regulation of ZNF418, therefore inhibiting its activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor that would inhibit JNK-mediated phosphorylation of substrates that could be imperative to ZNF418's activity, thus inhibiting ZNF418 function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor which would prevent phosphorylation events within the p38 MAPK pathway, potentially inhibiting phosphorylation of substrates that interact with ZNF418, leading to an inhibition of ZNF418's function. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib, a Src family kinase inhibitor, would inhibit Src kinases that might phosphorylate proteins interacting with ZNF418, thereby inhibiting the functional activity of ZNF418. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a protein kinase C (PKC) inhibitor that would inhibit PKC-mediated phosphorylation of proteins that could be involved in ZNF418's regulation, thus inhibiting ZNF418's function. | ||||||