ZNF396 Inhibitors
Chemical inhibitors of ZNF396 function through various molecular pathways to modulate its activity. LY294002 and Wortmannin are both inhibitors of the PI3K/Akt signaling pathway. LY294002 is a potent molecule that can disrupt the normal function of phosphoinositide 3-kinases, which are directly involved in the Akt signaling pathway that can regulate the activity of numerous transcription factors, including ZNF396. By inhibiting PI3K, LY294002 causes a decrease in Akt activity, which can lead to reduced functional activity of ZNF396. Similarly, Wortmannin, as a covalent inhibitor of PI3K, can lead to a downregulation of the Akt signaling pathway, which can result in a decrease in the functional activity of ZNF396.
Other chemicals act on different signaling cascades that can influence the function of ZNF396. PD98059 and U0126 target the MAPK/ERK pathway by inhibiting MEK, which is critical for the activation of ERK. Disruption of this pathway can result in reduced functional activation of many transcription factors, including ZNF396. SP600125 can inhibit c-Jun N-terminal kinases (JNK), part of stress-activated protein kinase pathways that regulate transcription factors, which can prevent the phosphorylation and activation of ZNF396. SB203580 specifically inhibits p38 MAPK, another pathway that can regulate transcription factor activity. Inhibition by SB203580 can thus affect the functional activity of ZNF396. Rapamycin, an inhibitor of mTOR, can suppress the activity of proteins regulated by this key signaling pathway, which includes ZNF396. MG132 targets the ubiquitin-proteasome system, leading to the accumulation of ubiquitinated proteins, and can inhibit the function of transcription factors by preventing their degradation. SN-38, by inhibiting topoisomerase I, can indirectly inhibit the function of ZNF396 by affecting the transcription machinery. ICG-001 disrupts the interaction of transcription factors with CREB-binding protein (CBP), which can inhibit the activity of ZNF396. Lastly, chelerythrine and GF109203X act as inhibitors of protein kinase C (PKC), leading to reduced phosphorylation and functional activity of transcription factors, including ZNF396.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are involved in the Akt signaling pathway. ZNF396, as a transcription factor, may be regulated by the Akt pathway. Inhibition of PI3K leads to reduced Akt activity, which could decrease the functional activity of ZNF396. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 inhibits MEK, which is part of the MAPK/ERK pathway. The MAPK/ERK pathway can regulate transcription factors including ZNF396. By inhibiting MEK, PD98059 prevents the activation of ERK, which could lead to the functional inhibition of ZNF396. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinases (JNK), which are part of stress-activated protein kinase pathways that can regulate transcription factors. Inhibition of JNK activity can prevent the phosphorylation and activation of transcription factors, potentially inhibiting ZNF396. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. p38 MAPK is involved in the regulation of transcription factors and their activity. Inhibition of p38 MAPK by SB203580 could result in functional inhibition of ZNF396 due to disruption of its regulatory pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a covalent inhibitor of PI3K, leading to downregulation of Akt signaling pathway. Since transcription factors can be influenced by Akt activity, the inhibition of PI3K by Wortmannin can result in functional inhibition of ZNF396. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a key regulator of cell growth and proliferation that also affects transcription factors. By inhibiting mTOR, Rapamycin can suppress the activity of proteins regulated by this pathway, which includes the functional activity of ZNF396. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK, which is upstream in the MAPK/ERK signaling pathway. This pathway is known to regulate transcription factors. Inhibition of MEK by U0126 can lead to reduced ERK activation and subsequent functional inhibition of ZNF396. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 inhibits the proteasome, which can lead to accumulation of ubiquitinated transcription factors, potentially including ZNF396. This accumulation can inhibit the function of transcription factors by preventing their proper degradation and recycling. | ||||||
SN 38 | 86639-52-3 | sc-203697 sc-203697A sc-203697B | 10 mg 50 mg 500 mg | $119.00 $342.00 $883.00 | 19 | |
SN-38 inhibits topoisomerase I, which is essential for DNA replication and transcription. As ZNF396 is a transcription factor, its activity relies on transcription machinery. By inhibiting topoisomerase I, SN-38 can indirectly inhibit the functional activity of ZNF396. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a potent inhibitor of protein kinase C (PKC). PKC is known to phosphorylate and regulate transcription factors. Inhibition of PKC by Chelerythrine can lead to a decrease in phosphorylation and functional activity of ZNF396. | ||||||