ZNF235 Activators
ZNF235 include a range of compounds that interact with various cellular pathways, leading to the activation of this zinc finger protein. Bisphenol A, Genistein, and Dibutyl phthalate share a common mechanism of mimicking natural estrogens, thus binding to and activating estrogen receptors. This activation can enhance the transcriptional regulation where ZNF235 is involved, as estrogen receptors can regulate gene expression via hormone-responsive elements to which ZNF235 may be responsive. Similarly, Retinoic acid acts by binding to retinoic acid receptors, potentially leading to the heterodimerization with other nuclear receptors and subsequent activation of ZNF235 within retinoic acid-responsive gene regulatory networks.
Trichostatin A and Sodium butyrate, both histone deacetylase inhibitors, can induce a relaxed chromatin state. This can facilitate the binding of transcription factors and other regulatory proteins to DNA, thereby possibly increasing the activity of ZNF235 through enhanced access to its binding sites on the genome. The compound 5-Aza-2'-deoxycytidine can lead to DNA hypomethylation, also potentially increasing ZNF235 activity by influencing its genomic interactions. Forskolin, by raising cAMP levels, can activate adenylate cyclase, thus enhancing the activity of transcriptional regulators like CREB-binding protein, which in turn can interact with and activate ZNF235. Compounds such as Epigallocatechin gallate and Resveratrol can alter the activity of redox-sensitive and other transcription factors, respectively, with downstream effects that can lead to the activation of ZNF235. Finally, ZnCl2 directly provides zinc ions which are essential for the structural and functional integrity of the zinc finger domains of ZNF235, directly leading to its activation, while Lithium chloride's inhibition of GSK-3 may also enhance the functional activity of ZNF235 through its effects on signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A can bind to estrogen receptors which may lead to the activation of certain zinc finger proteins, such as ZNF235, through estrogen receptor-mediated transcriptional activation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a phytoestrogen, has the capability to activate estrogen receptors, potentially causing the activation of ZNF235 through similar mechanisms as estrogen, given that ZNF235 can be regulated by hormone-responsive elements. | ||||||
Di-n-butyl phthalate | 84-74-2 | sc-257307 sc-257307A sc-257307B | 5 g 25 g 1 kg | $41.00 $52.00 $104.00 | 1 | |
Dibutyl phthalate, an environmental estrogen, could activate ZNF235 by mimicking the natural ligands of estrogen receptors, ultimately influencing the transcriptional activity where ZNF235 is involved. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, can lead to a more relaxed chromatin structure, potentially enhancing the binding of transcription factors to DNA and activating downstream zinc finger proteins such as ZNF235. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
5-Aza-2'-deoxycytidine, by inhibiting DNA methyltransferases, may induce hypomethylation of DNA and activate gene expression, potentially increasing the activity of ZNF235 in genomic binding and function. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid acts as a ligand for retinoic acid receptors which can heterodimerize with other nuclear receptors to regulate gene expression, potentially leading to the activation of ZNF235 in retinoic acid-responsive gene regulatory networks. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate, through its antioxidant properties, may alter redox-sensitive transcription factor activity and thereby influence the functional activity of ZNF235. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has been shown to activate sirtuin proteins which in turn can modulate the activity of various transcription factors, potentially leading to the activation of ZNF235 by altering its interaction with other DNA-binding proteins. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, as a histone deacetylase inhibitor, can lead to the enhancement of transcriptional activation and potentially increase the activity of ZNF235 through altered chromatin accessibility. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride influences glycogen synthase kinase 3 (GSK-3) activity, which is involved in various signaling pathways, potentially enhancing the functional activity of transcription factors including ZNF235. | ||||||