ZNF185, or Zinc Finger Protein 185, is part of the larger family of zinc finger proteins, which are characterized by the presence of zinc finger domains. These domains are protein motifs that can bind to specific DNA sequences, and they often play roles in DNA recognition, RNA packaging, lipid binding, protein folding, and more. Given their DNA-binding capabilities, many zinc finger proteins function as transcription factors, regulating gene expression by binding to specific DNA sequences and modulating the transcriptional activity of target genes. ZNF185, as a member of this family, may be involved in specific gene regulatory networks, influencing cellular processes by modulating the expression of particular target genes.
Inhibitors targeting ZNF185 would be molecules or strategies designed to modulate the function, expression, or stability of the ZNF185 protein. Given its potential role in gene regulation, inhibiting ZNF185 could alter specific gene expression profiles, thereby impacting the cellular processes governed by these genes. Potential inhibitors might include small molecules that bind directly to the zinc finger domains of ZNF185, preventing its interaction with DNA and thus its ability to influence gene transcription. Other inhibitors might target the protein-protein interaction domains of ZNF185, affecting its interactions with other cellular components and potentially its ability to form functional transcriptional complexes. Molecular tools, such as RNA interference or antisense oligonucleotides, could also be employed to modulate ZNF185 expression at the genetic level. Exploring the effects of ZNF185 inhibition can provide insights into its specific roles in gene regulation and the broader implications of modulating this regulatory network. Such investigations would deepen our understanding of the intricacies of gene regulation and the roles of zinc finger proteins in cellular biology.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-azacytidine can demethylate DNA, potentially down-regulating genes that are overexpressed due to hypermethylation, including FRMD4A. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA is an HDAC inhibitor that can alter gene transcription patterns. It may down-regulate genes in the FERM family, possibly including FRMD4A. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Given mTOR's role in regulating a variety of genes, Rapamycin might down-regulate FRMD4A or related family members by inhibiting mTOR signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. JNK signaling can influence various gene expressions, potentially down-regulating FRMD4A or its related proteins. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib inhibits multiple kinases and might down-regulate FRMD4A or related proteins by interfering with their associated signaling pathways. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib is an EGFR tyrosine kinase inhibitor. By affecting EGFR signaling, it might down-regulate genes in the FERM family, including FRMD4A. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 activates p53 by inhibiting its interaction with MDM2. This could lead to changes in the expression of various genes, including potential down-regulation of FRMD4A or its family members. | ||||||
ZM 336372 | 208260-29-1 | sc-202857 | 1 mg | $46.00 | 2 | |
ZM-336372 is a RAF kinase inhibitor. By affecting the RAF/MEK/ERK pathway, it could down-regulate genes like FRMD4A or its related proteins. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor. It affects protein turnover, which could influence the stability and expression of proteins like FRMD4A or its relatives. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
Ruxolitinib is a JAK1/2 inhibitor. JAK-STAT signaling influences various gene expressions, possibly down-regulating FRMD4A or its family members. |