ZNF180 Inhibitors
Chemical inhibitors of ZNF180 utilize diverse biochemical pathways to modulate the protein's function. Chelerythrine and GF109203X, for example, are potent inhibitors of protein kinase C (PKC), a kinase that can activate ZNF180 through phosphorylation. These inhibitors prevent the phosphorylation of ZNF180, thus maintaining it in an inactive state. Similarly, H-89 as a protein kinase A (PKA) inhibitor, targets another phosphorylation pathway that can impact ZNF180 function. By inhibiting PKA, H-89 prevents potential phosphorylation events that might be critical for the activity of ZNF180. LY294002 and Wortmannin both function as inhibitors of phosphoinositide 3-kinases (PI3K), thereby obstructing the PI3K/AKT signaling pathway. This inhibition can lead to reduced phosphorylation and subsequent regulation of ZNF180, as the pathway is known to be involved in the control of various proteins.
Further, Y-27632 operates by selectively inhibiting the Rho-associated protein kinase (ROCK), which affects actin cytoskeleton organization. This disruption can influence the localization and stability of ZNF180, affecting its functional capacity. PD98059 and U0126 both target the mitogen-activated protein kinase kinase (MEK) within the ERK/MAPK pathway. By inhibiting MEK, they consequently hinder the phosphorylation of regulatory proteins that interact with ZNF180, impacting its ability to function properly. SP600125, as an inhibitor of c-Jun N-terminal kinase (JNK), and SB203580, an inhibitor of p38 MAP kinase, both interfere with stress response pathways that can modulate ZNF180. PP2 abrogates the activity of Src family tyrosine kinases which can phosphorylate proteins associated with ZNF180, potentially leading to the inhibition of ZNF180 activity. Lastly, ICG-001 binds to CREB-binding protein, impacting the transcriptional activity of various proteins, including ZNF180, by disrupting necessary protein interactions within the transcriptional machinery.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a potent inhibitor of protein kinase C (PKC), and since PKC can phosphorylate ZNF180, leading to its activation, chelerythrine can inhibit the functional activity of ZNF180 by preventing its phosphorylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, LY294002 can block the PI3K/AKT pathway, which may be involved in the regulation or modification of ZNF180, resulting in the functional inhibition of ZNF180. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 selectively inhibits the Rho-associated protein kinase (ROCK). By inhibiting ROCK, Y-27632 affects actin cytoskeleton organization, which could be crucial for the functional localization or stability of ZNF180, thereby inhibiting its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is part of the ERK/MAPK pathway. By inhibiting this pathway, PD98059 can prevent the phosphorylation of proteins that regulate or interact with ZNF180, leading to the functional inhibition of ZNF180. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which may influence the phosphorylation state of proteins that interact with ZNF180. By inhibiting JNK, SP600125 can inhibit the functional activity of ZNF180 by preventing essential phosphorylation events. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase, which could play a role in stress response pathways that modulate the function of ZNF180. Inhibiting p38 MAP kinase with SB203580 can lead to functional inhibition of ZNF180 by disrupting these regulatory stress response pathways. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. Src kinases can phosphorylate a variety of proteins, potentially including those that interact with ZNF180. Inhibiting Src kinases with PP2 can prevent the phosphorylation and subsequent activation of ZNF180, leading to its functional inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor like LY294002 and can inhibit the PI3K/AKT pathway. By inhibiting this pathway, wortmannin can prevent the phosphorylation of proteins that interact with ZNF180, leading to functional inhibition of ZNF180. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK, which is involved in the ERK/MAPK pathway. By inhibiting MEK with U0126, the ERK/MAPK pathway is disrupted, which can prevent the phosphorylation of proteins that regulate or interact with ZNF180, leading to the functional inhibition of ZNF180. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
GF109203X, also known as bisindolylmaleimide I, is a potent inhibitor of PKC like chelerythrine. By inhibiting PKC, GF109203X can suppress the phosphorylation of ZNF180 or associated regulatory proteins, thereby inhibiting the functional activity of ZNF180. | ||||||